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US 9,000,136 B2Granted
Recombinant vaccinia virus having hepatitis C virus gene
AssigneesTokyo Metropolitan Institute of Medical Science, The Chemo-Sero-Therapeutic Research Institute
InventorsMichinori Kohara, Fukashi Murai
Life of this patent
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Abstract
Provided is a recombinant virus which is efficacious in preventing the onset of hepatitis C infection and has a high safety. Also provided is a vaccine for hepatitis C virus which contains the recombinant virus. A recombinant vaccinia virus which can express hepatitis C virus gene. The hepatitis C virus vaccine as described above contains the recombinant virus as described above.
Claims5
A recombinant vaccinia virus comprising an expression promoter and a DNA of (a) or (b) below:
- (a) DNA consisting of the nucleotide sequence of SEQ ID NO:2;
- or (b) DNA that hybridizes with DNA consisting of a nucleotide sequence complementary to the nucleotide sequence of SEQ ID NO:2, that has 90% or more homology with the nucleotide sequence of SEQ ID NO:2, and that codes for a nonstructural protein and a structural protein of hepatitis C virus.
Dependencies are inferred from the claim text.