Reagent and kit for early diagnosis of kidney disease
OwnerWallace B. Haigh, Donald L. Very, Jr.inventors
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Abstract
The invention provides reagents and methods for diagnosing kidney disease in a human or animal.
Claims23
A mixture of polyclonal antisera for diagnosing kidney disease in a human or animal, comprising a plurality of antibodies immunologically specific for each of a plurality of proteins, wherein the plurality of proteins comprises zinc alpha-2-glycoprotein, alpha-1 microglobulin, alpha-1-acid glycoprotein 1, alpha-1-acid glycoprotein 2, IgG kappa chain (IGKV1-5), IgG lambda chain, prostaglandin-H2 D-isomerase precursor, hepatocyte growth factor-like (HGFL) protein, urine protein 1, complement regulatory protein CD59, thrombin, hemopexin, alpha-2-HS-glycoprotein precursor, G(M2)activator protein, pancreatic stone protein, saposin precursor, pepsin, kininogen, alpha-1 B-glycoprotein, beta-trace 23kD glycoprotein, haptoglobin, gelsolin, and whey acid protein, and wherein said mixture of polyclonal antisera does not immunologically cross-react with serum albumin.
A diagnostic reagent comprising a mixture of polyclonal antisera or monoclonal antibodies immunologically specific for each of a plurality of proteins, wherein the plurality of proteins comprises zinc alpha-2-glycoprotein, alpha-1 microglobulin, alpha-1-acid glycoprotein 1, alpha-1-acid glycoprotein 2, IgG kappa chain (IGKV1-5), IgG lambda chain, prostaglandin-H2 D-isomerase precursor, hepatocyte growth factor-like (HGFL) protein, urine protein 1, complement regulatory protein CD59, thrombin, hemopexin, alpha-2-HS-glycoprotein precursor, G(M2)activator protein, pancreatic stone protein, saposin precursor, pepsin, kininogen, alpha-1B-glycoprotein, beta-trace 23kD glycoprotein, haptoglobin, gelsolin, and whey acid protein, and wherein the diagnostic reagent does not immunologically cross-react with serum albumin.
Dependencies are inferred from the claim text.