Crystalline oxidized glutathione and production method therefor
AssigneeKyowa Hakko Bio Co., Ltd.
InventorsKen Kimura, Kenta Fukumoto, Hiroshi Tanaka
Life of this patent
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Abstract
Provided is a novel crystal of oxidized glutathione hexahydrate. Crystal of oxidized glutathione hexahydrate is produced by cooling an aqueous solution containing oxidized glutathione to 15° C. or lower to precipitate a crystal of oxidized glutathione hexahydrate.
Claims8
A process for producing a crystal of oxidized glutathione hexahydrate having peaks at a diffraction angle (2θ) of 8.12°, 9.70°, 10.62°, 12.44°, 14.20°, 16.22°, 16.38°, 17.90°, 18.90°, 19.52°, 20.26°, 21.32°, 21.60°, 22.82°, 23.34°, 24.40°, 24.72°, 24.98°, 25.56°, 26.18°, 26.68°, 27.20°, 28.32°, 29.00°, 29.66°, 31.02°, 31.58°, 32.20°, 32.72°, 32.88°, 34.48° and 41.56° in powder X-ray diffraction comprising cooling an aqueous solution containing oxidized glutathione to 15° C. or lower to precipitate a crystal of oxidized glutathione hexahydrate, and then collecting the crystal of oxidized glutathione hexahydrate from the aqueous solution.
A process for producing a crystal of oxidized glutathione hexahydrate having peaks at a diffraction angle (2θ) of 8.12°, 9.70°, 10.62°, 12.44°, 14.20°, 16.22°, 16.38°, 17.90°, 18.90°, 19.52°, 20.26°, 21.32°, 21.60°, 22.82°, 23.34°, 24.40°, 24.72°, 24.98°, 25.56°, 26.18°, 26.68°, 27.20°, 28.32°, 29.00°, 29.66°, 31.02°, 31.58°, 32.20°, 32.72°, 32.88°, 34.48° and 41.56° in powder X-ray diffraction comprising adding or adding dropwise a solvent selected from the group consisting of alcohols and ketones to an aqueous solution containing oxidized glutathione at 15° C. or lower.
A process for producing a crystal of oxidized glutathione hexahydrate having peaks at a diffraction angle (2θ) of 8.12°, 9.70°, 10.62°, 12.44°, 14.20°, 16.22°, 16.38°, 17.90°, 18.90°, 19.52°, 20.26°, 21.32°, 21.60°, 22.82°, 23.34°, 24.40°, 24.72°, 24.98°, 25.56°, 26.18°, 26.68°, 27.20°, 28.32°, 29.00°, 29.66°, 31.02°, 31.58°, 32.20°, 32.72°, 32.88°, 34.48° and 41.56° in powder X-ray diffraction comprising adding or adding dropwise a solvent selected from the group consisting of methanol, ethanol, n-propanol and isopropyl alcohol to an aqueous solution containing oxidized glutathione at 15° C. or lower.
A process for producing a crystal of oxidized glutathione hexahydrate having peaks at a diffraction angle (2θ) of 8.12°, 9.70°, 10.62°, 12.44°, 14.20°, 16.22°, 16.38°, 17.90°, 18.90°, 19.52°, 20.26°, 21.32°, 21.60°, 22.82°, 23.34°, 24.40°, 24.72°, 24.98°, 25.56°, 26.18°, 26.68°, 27.20°, 28.32°, 29.00°, 29.66°, 31.02°, 31.58°, 32.20°, 32.72°, 32.88°, 34.48° and 41.56° in powder X-ray diffraction comprising adding or adding dropwise methanol to an aqueous solution containing oxidized glutathione at 15° C. or lower.
Dependencies are inferred from the claim text.