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US 9,000,054 B2Granted
Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer
AssigneeSenomyx, Inc.
InventorsCatherine Tachdjian, Donald S. Karanewsky, Xiao Qing Tang, Hanghui Liu
Life of this patent
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Abstract
The present invention includes methods of stabilizing one or more sweet enhancers when they are exposed to a light source as well as liquid compositions containing one or more sweet enhancers and one or more photostabilizers.
Claims16
A liquid composition comprising
- a compound having structural formula (II), or a salt or solvate thereof;
- and
- a phenol-based antioxidant, or a salt or solvate thereof, as a photostabilizer for the compound having structural formula (II);
- wherein:
- the phenol-based antioxidant is selected from the group consisting of a dihydrochalcone derivative, a flavanone derivative, a coumarine derivative, a phenylpropenoic carbonyl compound, and a combination thereof;
- the compound having structural formula (II):
- wherein,
- A is —OR9, —NO2, —NHOR9, —NR9COR10, —NR9R10, or —NR9CO2R10;
- R17 is hydrogen, alkyl, or substituted alkyl;
- X1 is —O—, —NR9—, or —S—;
- X2 is alkylene, substituted alkylene, heteroalkylene, or substituted heteroalkylene;
- m is 1;
- Y1 is
- X3 and X5 are independently a covalent bond, —O— or —NR9—;
- X4 is O;
- Rx is halo, —NO2, —CN, —OH, —NH2, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl;
- n is 0, 1, 2, or 3;
- Ry is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl, —NR9R10;
- and
- each R9 and R10 is independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl.
17 more elements
Dependencies are inferred from the claim text.