SHIP1 modulators and related methods
AssigneeThe University of British Columbia
InventorsXiaoxia Wang, Labros George Meimetis, Matthew Bruce Nodwell, Raymond Andersen
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Abstract
Compounds of structure (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2 and A are as defined herein are disclosed. Such compounds have enhanced water solubility and have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Enantioselective methods for preparation of compounds of structure (I), compositions comprising a compound of structure (I) in combination with a pharmaceutically acceptable carrier or diluents and methods of SHIP1 modulation by administration of such compounds to an animal in need thereof are also disclosed.
Claims16
A compound having the following structure (I):
- or a pharmaceutically acceptable salt or stereoisomer thereof, wherein
- R1 and R2 are each hydroxyl;
- A is —CHR3—, —C(R4)(R5)NR6—, —NR6C(R4)(R5)—, —C(═O)— or —C(═N—OR6)—;
- R3 is —OR6, —OC(═O)R6 or —NR6R7;
- R4 and R5 are each hydrogen or both of R4 and R5 may be taken together to form an oxo moiety;
- and
- R6 and R7 are, at each occurrence, independently hydrogen, alkyl, optionally substituted aryl or optionally substituted aralkyl.
A compound selected from the group consisting of:
- or a pharmaceutically acceptable salt or stereoisomer thereof.
Dependencies are inferred from the claim text.