US 9,000,037 B2 · Precursors of glutamate derivatives

Abstract

This invention relates to novel precursors suitable for 18F radiolabeling of glutamate derivatives, methods for preparing such compounds and its intermediates, compositions comprising such compounds, kits comprising such compounds or compositions and methods for 18F radiolabeling of glutamate derivatives wherein the obtained 18F radiolabeled glutamate derivatives are suitable for diagnostic imaging by Positron Emission Tomography (PET) of proliferative diseases e.g. tumor in mammals.

Claims9

Dependent claims

A compound of the formula I

wherein
R1 is triphenylmethyl,
A is selected from the group consisting of:
a) Monocyclic aryl,
b) Bicyclic aryl,
c) Biaryl,
d) Monocyclic heteroaryl, and
e) Bicyclic heteroaryl
optionally, A is bearing one or more substituents selected from the group consisting of:
a) Halogen,
b) Nitro,
c) Alkyl,
d) Trifluoromethyl, and
e) Z,
wherein Z is
where R1 is triphenylmethyl, and
# indicates the position of the bond to A, or
a single isomer, tautomer, diastereomer, enantiomer or stereoisomer thereof, or mixtures thereof, or a suitable salt thereof.

15 more elements

Dependencies are inferred from the claim text.

Facts

Application

14/115,127Filed 30 Apr 2012

Priority

EP 110750773 May 2011

Published

US 2014/0243532 A128 Aug 2014

Granted

7 Apr 2015

Term ends

Not estimatedThe source records don’t support an estimate.

Classification14 codes

C07C 309/77
Having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton: containing carboxyl…
C07B 59/001
Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se: acyclic or carbocyclic compounds
C07C 227/16
From compounds containing already amino and carboxyl groups or derivatives thereof: by reactions not involving the amino or carboxyl groups
C07C 227/18
From compounds containing already amino and carboxyl groups or derivatives thereof: by reactions involving amino or carboxyl groups, e.g.…

Precursors of glutamate derivatives

Life of this patent

Precursors of glutamate derivatives

Life of this patent

Abstract

Claims9