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US 9,000,031 B2Granted
Thioxanthone-based autophagy inhibitor therapies to treat cancer
AssigneeSpectrum Pharmaceuticals, Inc.
InventorsSteffan Nawrocki, Jennifer Carew, Guru Reddy
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Abstract
The present specification provides compositions comprising a thioxanthone-based autophagy inhibitor and/or a cancer therapeutic autophagy inducing compound, pharmaceutical kits comprising these compositions, and methods of treating cancer using such compounds, compositions and kits. Additionally, the present specification provides methods of treating cancer using a thioxanthone-based autophagy inhibitor and a radiotherapy.
Claims22
A pharmaceutical composition comprising:
- a) a therapeutically effective amount of a thioxanthone-based autophagy inhibitor;
- b) a therapeutically effective amount of a cancer therapeutic autophagy inducing compound;
- and c) a pharmaceutically acceptable carrier, wherein the thioxanthone-based autophagy inhibitor is 1-((2(Diethylamino)ethyl)amino)-4-methylthioxanthen-9-one, 1-(2-diethylaminoethylamino)-4-(hydroxymethyl)-9-thioxanthenone, N-[[1-[[2-(diethylamino)ethyl]amino]-9-oxo-9H-thiaxanthen-4-yl]methyl]methanesulfonamide, indazole analogues thereof, or salts thereof, and wherein the cancer therapeutic autophagy inducing compound is an arsenic trioxide, an etoposide, a rapamycin, a histone deacetylase inhibitor, a tyrosine kinase inhibitor, a tamoxifen, a temozolomide, an imatinib, or a bortezomib.
A pharmaceutical kit comprising:
- a) a pharmaceutical composition comprising a thioxanthone-based autophagy inhibitor and a pharmaceutically acceptable carrier, and b) a pharmaceutical composition comprising a cancer therapeutic autophagy inducing compound and a pharmaceutically acceptable carrier, wherein the thioxanthone-based autophagy inhibitor is 1-((2(Diethylamino)ethyl)amino)-4-methylthioxanthen-9-one, 1-(2-diethylaminoethylamino)-4-(hydroxymethyl)-9-thioxanthenone, N-[[1-[[2-(diethylamino)ethyl]amino]-9-oxo-9H-thiaxanthen-4-yl]methyl]methanesulfonamide, indazole analogues thereof, or salts thereof, and wherein the cancer therapeutic autophagy inducing compound is an arsenic trioxide, an etoposide, a rapamycin, a histone deacetylase inhibitor, a tyrosine kinase inhibitor, a tamoxifen, a temozolomide, an imatinib, or a bortezomib.
Dependencies are inferred from the claim text.