Pharmaceutical composition
AssigneeEisai R&D Management Co., Ltd.
InventorsMark Spyvee, Takashi Satoh, Jonathan Eric Carlson
Life of this patent
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Abstract
The present invention provides compounds of Formula I: along with pharmaceutical compositions containing the same, and methods of use thereof in subjects in need of treatment.
Claims71
A method of treating cancer in a mammal, comprising the step of administering to the mammal a pharmaceutical composition comprising a compound of formula I:
- wherein:
- one of R1a and R1b is hydrogen, and the other is methyl;
- or R1a and R1b are taken together to form a cyclopropyl ring;
- R2 is methyl or fluoromethyl;
- R3 is methyl;
- R4 is hydrogen, halo, fluoromethyl, methyl, methoxy, or fluoromethoxy;
- R5 is hydrogen, halo, fluoromethyl, methyl, methoxy, or fluoromethoxy;
- R6 is hydrogen, halo, methyl, or methoxy;
- R7 is hydrogen, halo, methyl, or methoxy;
- and
- X is oxygen;
- or a pharmaceutically acceptable salt thereof,
- wherein the cancer is selected from the group consisting of skin cancer, breast cancer, colorectal cancer, prostate cancer, kidney cancer, ovarian cancer, cervical cancer, endometrial cancer, glioblastoma, lung cancer, head and neck cancer, medulloblastoma, and urinary tract cancer.
A method of treating cancer in a mammal, comprising the step of administering to the mammal a pharmaceutical composition comprising a compound:
- or a pharmaceutically acceptable salt thereof,
- wherein the cancer is selected from the group consisting of skin cancer, breast cancer, colorectal cancer, prostate cancer, kidney cancer, ovarian cancer, cervical cancer, endometrial cancer, glioblastoma, lung cancer, head and neck cancer, medulloblastoma, and urinary tract cancer.
A method of treating cancer in a mammal, comprising the step of administering to the mammal a pharmaceutical composition comprising a compound:
- or a pharmaceutically acceptable salt thereof,
- wherein the cancer is selected from the group consisting of skin cancer, breast cancer, colorectal cancer, prostate cancer, kidney cancer, ovarian cancer, cervical cancer, endometrial cancer, glioblastoma, lung cancer, head and neck cancer, medulloblastoma, and urinary tract cancer.
A compound selected from the group consisting of:
- or a pharmaceutically acceptable salt thereof.
A compound selected from the group consisting of:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.