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US 9,000,016 B2Granted
1,3,4-Oxadiazoles-2-thio derivatives as sphingosine-1 phosphate receptors modulators
AssigneeAllergan, Inc.
InventorsJanet A. Takeuchi, Ling Li, Wha-Bin Im, Ken Chow
Life of this patent
Estimating the term…
Abstract
The present invention relates to substituted 1,3,4-oxadiazoles-2-thio derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
Claims7
A compound having Formula I, its enantiomers, diastereoisomers, tautomers or a pharmaceutically acceptable salt thereof,
- wherein:
- X is S, SO or SO2;
- R1 is hydrogen, halogen, substituted or unsubstituted C1-6 alkyl, NO2, CN, C(O)R13 or hydroxyl;
- R2 is hydrogen, halogen, substituted or unsubstituted C1-6 alkyl, NO2, CN, C(O)R13 or hydroxyl;
- R3 is hydrogen, halogen, substituted or unsubstituted C1-6 alkyl, NO2, CN, C(O)R13 or hydroxyl;
- R4 is hydrogen, halogen, substituted or unsubstituted C1-6 alkyl, NO2, CN, C(O)R13 or hydroxyl;
- R5 is hydrogen, halogen, substituted or unsubstituted C1-6 alkyl, NO2, CN, C(O)R13 or hydroxyl;
- R6 is H or C1-6 alkyl;
- R7 is hydrogen, halogen, substituted or unsubstituted C1-6 alkyl, NO2, CN, C(O)R13 or hydroxyl;
- R8 is CH, S, O, N, NH or CH2;
- R9 is CH or CH2;
- R10 is hydrogen, halogen, substituted or unsubstituted C1-3 alkyl, NO2, CN, C(O)R13 or hydroxyl;
- R11 is H or C1-3 alkyl;
- R12 is OPO3H2, carboxylic acid, PO3H2, —P(O)MeOH, —P(O)(H)OH or OR14;
- a is 0 or 1;
- b is 1, 2 or 3;
- R13 is OH or C1-3 alkyl;
- R14 is H or C1-3 alkyl;
- when a is 1 then
- and when a is 0 then
- and R8 is S, O, NH or CH2.
18 more elements
Dependencies are inferred from the claim text.