Amides of acetic and propionic acids
AssigneeBayer Intellectual Property GmbH
InventorsJoachim Luithle, Frank-Gerhard Bob, Christina Erb, Katrin Schnizler, Timo Flessner, Marja V. Kampen, Christoph Methfessel
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Abstract
The invention relates to novel amides of acetic and propionic acids, methods for production and use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning ability and memory.
Claims16
A method of treating a cognitive impairment in a patient in need thereof, comprising administering to the patient a compound represented by Formula (I):
- wherein:
- R1 represents a 1-azabicyclo[m.n.p]alkyl radical having 7 to 11 ring atoms, wherein the bicycloalkyl radical is optionally substituted by (C1-C6)-alkyl;
- m represents a value of 2 or 3;
- n represents a value of 2 or 3;
- p represents a value of 1, 2, or 3;
- A represents a methylene or an ethylene;
- R2 represents a 8- to 10-membered ring comprising heteroaryl, naphthyl, or azulenyl, wherein the ring is optionally substituted by a radical selected from the group of halogen, formyl, —CO—NR4R5, —CO—OR6, —NR7R8, —NR9—CO—R10, cyano, trifluoromethyl, trifluoromethoxy, nitro, optionally hydroxyl, amino, —NH—CO—R11, or cyano-substituted (C1-C6)-alkyl, (C1-C6)-alkoxy, (C1-C6)-alkylthio, wherein the R4, R5, R6, R7, R8, R9, R10 and R11 independently represent hydrogen, (C1-C6)-alkyl, phenyl, or benzyl;
- and
- R3 represents a hydrogen or (C1-C6)-alkyl;
- or
- a physiological acceptable salt, enantiomer, or diastereomer thereof.
A method of treating a cognitive impairment in a patient in need thereof, comprising administering to the patient a pharmaceutical composition comprising:
- i) a compound represented by Formula (I):
- wherein:
- R1 represents a 1-azabicyclo[m.n.p]alkyl radical having 7 to 11 ring atoms, wherein the bicycloalkyl radical is optionally substituted by (C1-C6)-alkyl;
- m represents a value of 2 or 3;
- n represents a value of 2 or 3;
- p represents a value of 1, 2, or 3;
- A represents a methylene or an ethylene;
- R2 represents a 8- to 10-membered ring comprising heteroaryl, naphthyl, or azulenyl, wherein the ring is optionally substituted by a radical selected from the group of halogen, formyl, —CO—NR4R5, —CO—OR6, —NR7R8, —NR9—CO—R10, cyano, trifluoromethyl, trifluoromethoxy, nitro, optionally hydroxyl, amino, —NH—CO—R11, or cyano-substituted (C1-C6)-alkyl, (C1-C6)-alkoxy, (C1-C6)-alkylthio, wherein the R4, R5, R6, R7, R8, R9, R10 and R11 independently represent hydrogen, (C1-C6)-alkyl, phenyl, or benzyl;
- and
- R3 represents a hydrogen or (C1-C6)-alkyl;
- or
- a physiological acceptable salt, enantiomer, or diastereomer thereof;
- and ii) one or more pharmaceutically acceptable carriers or excipients.
Dependencies are inferred from the claim text.