Organic compounds

A compound of Formula I

• wherein
• (i) R1 is H or C1-4 alkyl;
• (ii) R4 is H or C1-4 alkyl and R2 and R3 are, independently, H or C1-4 alkyl, aryl, heteroaryl, heteroarylalkoxy, arylalkoxy, heteroarylalkyl or arylalkyl;
• (iii) R5 is a substituted heteroarylalkyl, or R5 is attached to one of the nitrogen atoms on the pyrazolo portion of Formula I and is a moiety of Formula A
• wherein X, Y and Z are, independently, N or C;
• R8, R9, R11 and R12 are independently H or halogen;
• and R10 is halogen, alkyl, cycloalkyl, haloalkyl, aryl, heteroaryl, or thiadiazolyl, diazolyl, triazolyl, tetrazolyl, arylcarbonyl, alkylsulfonyl, heteroarylcarbonyl, or alkoxycarbonyl;
• provided that when X, Y, or Z is nitrogen, R8, R9, or R10, respectively, is not present;
• (iv) R6 is H, alkyl, aryl, heteroaryl, arylalkyl, arylamino, heterarylamino, N,N-dialkylamino, N,N-diarylamino, or N-aryl-N-(arylalkyl)amino;
• and
• (v) n=0 or 1;
• (vi) when n=1, A is —C(R13R14)—
• wherein R13 and R14, are, independently, H or C1-4 alkyl, aryl, heteroaryl, heteroarylalkoxy, arylalkoxy, heteroarylalkyl or arylalkyl,
• wherein
• aryl is optionally substituted with C1-4 alkyl, halogen, haloC1-4 alkyl, hydroxy, carboxy or an additional aryl or heteroaryl;
• and
• heteroaryl is optionally substituted with C1-4 alkyl, halogen, haloC1-4 alkyl, hydroxy or carboxy;
• in free, salt or physiological hydrolysable and acceptable ester prodrug form.