Protein kinase inhibitors
AssigneesArizona Board of Regents on Behalf of the University of Arizona, Astex Pharmaceuticals, Inc.
InventorsLaurence H. Hurley, Daruka Mahadevan, David J. Bearss, Hariprasad Vankayalapati, Steven L. Warner, James Welsh, Sridevi Bashyam
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Abstract
Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.
Claims12
A compound having the following structure (III-1-3):
- or a stereoisomer, prodrug, tautomer or pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.