Macrophage migration inhibitory factor antagonists and methods of using same
AssigneeUniversity of Louisville Research Foundation, Inc.
InventorsRobert A. Mitchell, John O. Trent, Jason B. Meier
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Abstract
Methods of inhibiting one or more biological activities of Macrophage migration inhibitory factor (MIF) polypeptides are provided using an MIF inhibitory compound. The methods include therapeutic methods for treating cancers and inflammatory diseases.
Claims7
A method of inhibiting a biological activity of a Macrophage migration inhibitory factor (MIF) polypeptide, comprising contacting the MIF polypeptide with a compound having a structure of Formula (I):
- wherein:
- each R is independently H, halo, OH, alkyl, substituted alkyl, aryl, amino, or carboxyl;
- R1 is iodo;
- R2 is H, halo, OH, alkyl, substituted alkyl, aryl, or amino;
- and
- n is an integer from 0 to 5.
A method for inhibiting a biological activity of a Macrophage migration inhibitory factor (MIF) polypeptide, comprising contacting the MIF polypeptide with 4-iodo-6-phenylpyrimidine.
Dependencies are inferred from the claim text.