Pharmaceutically active compounds as Axl inhibitors

Compounds having the general formula (I)

• wherein
• A represents C—R10, N;
• B represents C—R11, N;
• D represents one of the following heterocycles
• R1, R4, R88, R92, R100 are selected independently of each other from —H, —F, —Cl, —Br, —I, —OH, —NH2, —NHR19, —NR19R20, —OCH3, —OC2H5, —OC3H7, —OCH(CH3)2, —OC(CH3)3, —OC4H9, —NO2, —CHO, —COCH3, —COC2H5, —O-cyclo-C3H5, —OCH2-cyclo-C3H5, —O—C2H4-cyclo-C3H5, —OPh, —COC3H7, —COCH(CH3)2, —COC(CH3)3, —COOH, —COOCH3, —COOC2H5, —COOC3H7, —COOCH(CH3)2, —COOC(CH3)3, —OOC—CH3, —OOC—C2H5, —OOC—C3H7, —OOC—CH(CH3)2, —OOC—C(CH3)3, —NHCH3, —NHC2H5, —NHC3H7, —NHCH(CH3)2, —NHC(CH3)3, —N(CH3)2, —N(C2H5)2, —N(C3H7)2, —N[CH(CH3)2]2, —N[C(CH3)3]2, —OCF3, —OC2F5, —CH2F, —CHF2, —CF3, —CH2CI, —CH2Br, —CH2I, —CH2—CH2F, —CH2—CHF2, —CH2—CF3, —CH2—CH2CI, —CH2—CH2Br, —CH2—CH2I, cyclo-C3H5, —CH2-cyclo-C3H5, —CH3, —C2H5, —C3H7, —CH(CH3)2, —C4H9, —CH2—CH(CH3)2, —CH(CH3)—C2H5, —C(CH3)3, —C5H11, —CH(CH3)—C3H7, —CH2—CH(CH3)—C2H5, —CH(CH3)—CH(CH3)2, —C(CH3)2—C2H5, —CH2—C(CH3)3, —CH(C2H5)2, —C2H4—CH(CH3)2, —C6H13, —C3H6—CH(CH3)2, —C2H4—CH(CH3)—C2H5, —CH(CH3)—C4H9, —CH2—CH(CH3)—C3H7, —CH(CH3)—CH2—CH(CH3)2, —CH(CH3)—CH(CH3)—C2H5, —CH2—CH(CH3)—CH(CH3)2, —CH2—C(CH3)2—C2H5, —C(CH3)2—C3H7, —C(CH3)2—CH(CH3)2, —C2H4—C(CH3)3, —CH(CH3)—C(CH3)3, —CH═CH2, —CH2—CH═CH2, —C(CH3)═CH2, —CH═CH—CH3, —C2H4—CH═CH2, —CH2—CH═CH—CH3, —CH═CH—C2H5, —CH2—C(CH3)═CH2, —CH(CH3)—CH═CH, —CH═C(CH3)2, —C(CH3)═CH—CH3, —CH═CH—CH═CH2, —C3H6—CH═CH2, —C2H4—CH═CH—CH3, —CH2—CH═CH—C2H5, —CH═CH—C3H7, —CH2—CH═CH—CH═CH2, —CH═CH—CH═CH—CH3, —CH═CH—CH2—CH═CH2, —C(CH3)═CH—CH═CH2, —CH═C(CH3)—CH═CH2, —CH═CH—C(CH3)═CH2, —C2H4—C(CH3)═CH2, —CH2—CH(CH3)—CH═CH2, —CH(CH3)—CH2—CH═CH2, —CH2—CH═C(CH3)2, —CH2—C(CH3)═CH—CH3, —CH(CH3)—CH═CH—CH3, —CH═CH—CH(CH3)2, —CH═C(CH3)—C2H5, —C(CH3)═CH—C2H5, —C(CH3)═C(CH3)2, —C(CH3)2—CH═CH2, —CH(CH3)—C(CH3)═CH2, —C(CH3)═CH—CH═CH2, —CH═C(CH3)—CH═CH2, —CH═CH—C(CH3)═CH2, —C4H5—CH═CH2, —C3H6—CH═CH—CH3, —C2H4—CH═CH—C2H5, —CH2—CH═CH—C3H7, —CH═CH—C4H9, —C3H6—C(CH3)═CH2, —C2H4—CH(CH3)—CH═CH2, —CH2—CH(CH3)—CH2—CH═CH2, —CH(CH3)—C2H4—CH═CH2, —C2H4—CH═C(CH3)2, —C2H4—C(CH3)═CH—CH3, —CH2—CH(CH3)—CH═CH—CH3, —CH(CH3)—CH2—CH═CH—CH3, —CH2—CH═CH—CH(CH3)2, —CH2—CH═C(CH3)—C2H5, —CH2—C(CH3)═CH—C2H5, —CH(CH3)—CH═CH—C2H5, —CH═CH—CH2—CH(CH3)2, —CH═CH—CH(CH3)—C2H5, —CH═C(CH3)—C3H7, —C(CH3)═CH—C3H7, —CH2—CH(CH3)—C(CH3)═CH2, —CH(CH3)—CH2—C(CH3)═CH2, —CH(CH3)—CH(CH3)—CH═CH2, —CH2—C(CH3)2—CH═CH2, —C(CH3)2—CH2—CH═CH2, —CH2—C(CH3)═C(CH3)2, —CH(CH3)—CH═C(CH3)2, —C(CH3)2—CH═CH—CH3, —CH(CH3)—C(CH3)═CH—CH3, —CH═C(CH3)—CH(CH3)2, —C(CH3)═CH—CH(CH3)2, —C(CH3)═C(CH3)—C2H5, —CH═CH—C(CH3)3, —C(CH3)2—C(CH3)═CH2, —CH(C2H5)—C(CH3)═CH2, —C(CH3)(C2H5)—CH═CH2, —CH(CH3)—C(C2H5)═CH2, —CH2—C(C3H7)═CH2, —CH2—C(C2H5)═CH—CH3, —CH(C2H5)—CH═CH—CH3, —C(C4H9)═CH2, —C(C3H7)═CH—CH3, —C(C2H5)═CH—C2H5, —C(C2H5)═C(CH3)2, —C[C(CH3)3]═CH2, —C[CH(CH3)(C2H5)]═CH2, —C[CH2—CH(CH3)2]═CH2, —C2H4—CH═CH—CH═CH2, —CH2—CH═CH—CH2—CH═CH2, —CH═CH—C2H4—CH—CH2, CH2—CH—CH═CH—CH═CH3, —CH═CH—CH2—CH═CH—CH3, —CH═CH—CH═CH—C2H5, —CH2—CH═CH—C(CH3)═CH2, —CH2—CH═C(CH3)—CH═CH2, —CH2—C(CH3)═CH—CH═CH2, —CH(CH3)—CH═CH—CH═CH2, —CH═CH—CH2—C(CH3)═CH2, —CH═CH—CH(CH3)—CH═CH2, —CH═C(CH3)—CH2—CH═CH2, —C(CH3)═CH—CH2—CH═CH2, —CH═CH—CH═C(CH3)2, —CH═CH—C(CH3)═CH—CH3, —CH═C(CH3)—CH═CH—CH3, —C(CH3)═CH—CH═CH—CH3, —CH═C(CH3)—C(CH3)═CH2, —C(CH3)═CH—C(CH3)═CH2, —C(CH3)═C(CH3)—CH═CH2, CH—CH═CH—CH═CH—CH2, —C≡CH, —C≡C—CH3, —CH2—C≡CH, —C2H4—C≡CH, —CH2—C≡C—CH3, —C≡C—C2H5, —C3H6—C≡CH, —C2H4—C═C—CH3, —CH2—C═C—C2H5, —C≡C—C3H7, —CH(CH3)—C≡CH, —CH2—CH(CH3)—C≡CH, —CH(CH3)—CH2—C≡CH, —CH(CH3)—C≡C—CH3, —C4H8—C≡CH, —C3H6—C≡C—CH3, —C2H4—C═C—C2H5, —CH2—C═C—C3H7, —C≡C—C4H9, —C2H4—CH(CH3)—C═CH, —CH2—CH(CH3)—CH2—C≡CH, —CH(CH3)—C2H4—C≡CH, —CH2—CH(CH3)—C≡C—CH3, —CH(CH3)—CH2—C═C—CH3, —CH(CH3)—C≡C—C2H5, —CH2—C═C—CH(CH3)2, —C═C—CH(CH3)—C2H5, —C≡C—CH2—CH(CH3)2, —C═C—C(CH3)3, —CH(C2H5)—C═C—CH3, —C(CH3)2—C═C—CH3, —CH(C2H5)—CH2—C≡CH, —CH2—CH(C2H5)—C≡CH, —C(CH3)2—CH2—C≡CH, —CH2—C(CH3)2—C≡CH, —CH(CH3)—CH(CH3)—C≡CH, —CH(C3H7)—C≡CH, —C(CH3)(C2H5)—C≡CH, —C═C—C≡CH, —CH2—C═C—C≡CH, —C═C—C═C—CH3, —CH(C≡CH)2, —C2H4—C≡C—C≡CH, —CH2—C═C—CH2—C≡CH, —C═C—C2H4—C≡CH, —CH2—C≡C—C≡C—CH3, —C═C—CH2—C≡C—CH3, —C≡C—C═C—C2H5, —C≡C—CH(CH3)—C≡CH, —CH(CH3)—C≡C—C≡CH, —CH(C≡CH)—CH2—C≡CH, —C(C≡CH)2—CH3, —CH2—CH(C≡CH)2, —CH(C≡CH)—C≡C—CH3;
• R21, R35, R36;
• R2 and R3 are selected independently of each other from —R88, —R37, —R38, —R54, —O—R54, —R55, —O—R55, —R56, —O—R56, —R57, —O—R57, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl or C1-6alkoxy groups represented by R88 are optionally mono- or polysubstituted by —OH, —F, —Cl, —Br, —I, —O—R71, R72, —R138, —COOH, —COOCH3, —COOC2H5, —COOC3H7, —COOCH(CH3)2, —COOC(CH3)3, —(C═O)—NR16R17, —SO2—NR16R17, —SOm—R16R17, —CR16R17H, —NR16R17;
• or R2 and/or R3 are selected independently of each other from —O—R18, —O—CR73R74—R18, —O—CR73R74—CR75R76—R18, —O—CR73R74—CR75R76—CR77R78—R18, —O—CR73R74—CR75R76—CR77R78—CR79R80—R18, —O—CR73R74—CR75R76—CR77R78—CR79R80—CR81R82—R18, —O—CR73R74—CR75R76—CR77R78—CR79R80—CR81R82—CR83R84—R18,
• R73-R84 independently of each other represent —H, —OH, —F, —Cl, —Br, —I, —R85;
• R18 represents —H, —OH, —F, —Cl, —Br, —I, —O—R86, —R87, —COOH, —COOCH3, —COOC2H5, —COOC3H7, —COOCH(CH3)2, —COOC(CH3)3, —(C═O)—NR16R17, —SO2—NR16R17, —SOm—R16R17, —CR16R17H, —NR16R17;
• m=0, 1, 2;
• R5 and R6, which may be the same or different, represent —H, —OH, —F, —Cl, —Br, —I, —CN, —NO2, —CH3, —C2H5, —C3H7, —CH(CH3)2, —C4H9, —CH2—CH(CH3)2, cyclo-C3H5, —CH2-cyclo-C3H5, —CH(CH3)—C2H5, —C(CH3)3, —C5H11, —CH(CH3)—C3H7, —CH2—CH(CH3)—C2H5, —CH(CH3)—CH(CH3)2, —C(CH3)2—C2H5, —CH2—C(CH3)3, —CH(C2H5)2, —C2H4—CH(CH3)2, —C6H13, —C3H6—CH(CH3)2, —C2H4—CH(CH3)—C2H5, —CH(CH3)—C4H9, —CH2—CH(CH3)—C3H7, —CH(CH3)—CH2—CH(CH3)2, —CH(CH3)—CH(CH3)—C2H5, —CH2—CH(CH3)—CH(CH3)2, —CH2—C(CH3)2—C2H5, —C(CH3)2—C3H7, —C(CH3)2—CH(CH3)2, —C2H4—C(CH3)3, —CH(CH3)—C(CH3)3, —CH═CH2, —CH2—CH═CH2, —C(CH3)═CH2, —CH═CH—CH3, —C2H4—CH═CH2, —CH2—CH═CH—CH3, —CH═CH—C2H5, —CH2—C(CH3)═CH2, —CH(CH3)—CH═CH, —CH═C(CH3)2, —C(CH3)═CH—CH3, —CH═CH—CH═CH2, —C3H6—CH═CH2, —C2H4—CH═CH—CH3, —CH2—CH═CH—C2H5, —CH═CH—C3H7, —CH2—CH═CH—CH═CH2, —CH═CH—CH═CH—CH3, —CH═CH—CH2—CH═CH2, —C(CH3)═CH—CH═CH2, —CH═C(CH3)—CH═CH2, —CH═CH—C(CH3)═CH2, —C2H4—C(CH3)═CH2, —CH2—CH(CH3)—CH═CH2, —CH(CH3)—CH2—CH═CH2, —CH2—CH═C(CH3)2, —CH2—C(CH3)═CH—CH3, —CH(CH3)—CH═CH—CH3, —CH═CH—CH(CH3)2, —CH═C(CH3)—C2H5, —C(CH3)═CH—C2H5, —C(CH3)═C(CH3)2, —C(CH3)2—CH═CH2, —CH(CH3)—C(CH3)═CH2, —C(CH3)═CH—CH═CH2, —CH═C(CH3)—CH═CH2, —CH═CH—C(CH3)═CH2, —C4H5—CH═CH2, —C3H6—CH═CH—CH3, —C2H4—CH═CH—C2H5, —CH2—CH═CH—C3H7, —CH═CH—C4H9, —C3H6—C(CH3)═CH2, —C2H4—CH(CH3)—CH═CH2, —CH2—CH(CH3)—CH2—CH═CH2, —CH(CH3)—C2H4—CH═CH2, —C2H4—CH═C(CH3)2, —C2H4—C(CH3)═CH—CH3, —CH2—CH(CH3)—CH═CH—CH3, —CH(CH3)—CH2—CH═CH—CH3, —CH2—CH═CH—CH(CH3)2, —CH2—CH═C(CH3)—C2H5, —CH2—C(CH3)═CH—C2H5, —CH(CH3)—CH═CH—C2H5, —CH═CH—CH2—CH(CH3)2, —CH═CH—CH(CH3)—C2H5, —CH═C(CH3)—C3H7, —C(CH3)═CH—C3H7, —CH2—CH(CH3)—C(CH3)═CH2, —CH(CH3)—CH2—C(CH3)═CH2, —CH(CH3)—CH(CH3)—CH═CH2, —CH2—C(CH3)2—CH═CH2, —C(CH3)2—CH2—CH═CH2, —CH2—C(CH3)═C(CH3)2, —CH(CH3)—CH═C(CH3)2, —C(CH3)2—CH═CH—CH3, —CH(CH3)—C(CH3)═CH—CH3, —CH═C(CH3)—CH(CH3)2, —C(CH3)═CH—CH(CH3)2, —C(CH3)═C(CH3)—C2H5, —CH═CH—C(CH3)3, —C(CH3)2—C(CH3)═CH2, —CH(C2H5)—C(CH3)═CH2, —C(CH3)(C2H5)—CH═CH2, —CH(CH3)—C(C2H5)═CH2, —CH2—C(C3H7)═CH2, —CH2—C(C2H5)═CH—CH3, —CH(C2H5)—CH═CH—CH3, —C(C4H9)═CH2, —C(C3H7)═CH—CH3, —C(C2H5)═CH—C2H5, —C(C2H5)═C(CH3)2, —C[C(CH3)3]═CH2, —C[CH(CH3)(C2H5)]═CH2, —C[CH2—CH(CH3)2]═CH2, —C2H4—CH═CH—CH═CH2, —CH2—CH═CH—CH2—CH═CH2, —CH═CH—C2H4—CH═CH2, —CH2—CH═CH—CH═CH—CH3, —CH═CH—CH2—CH═CH—CH3, —CH═CH—CH═CH—C2H5, —CH2—CH═CH—C(CH3)═CH2, —CH2—CH═C(CH3)—CH═CH2, —CH2—C(CH3)═CH—CH═CH2, —CH(CH3)—CH═CH—CH═CH2, —CH═CH—CH2—C(CH3)═CH2, —CH═CH—CH(CH3)—CH═CH2, —CH═C(CH3)—CH2—CH═CH2, —C(CH3)═CH—CH2—CH═CH2, —CH═CH—CH═C(CH3)2, —CH═CH—C(CH3)═CH—CH3, —CH═C(CH3)—CH═CH—CH3, —C(CH3)═CH—CH═CH—CH3, —CH═C(CH3)—C(CH3)═CH2, —C(CH3)═CH—C(CH3)═CH2, —C(CH3)═C(CH3)—CH═CH2, —CH═CH—CH═CH—CH═CH2, —C≡CH, —C≡C—CH3, —CH2—C≡CH, —C2H4—C≡CH, —CH2—C≡C—CH3, —C≡C—C2H5, —C2H4—C≡C—CH3, —CH2—C≡C—C2H5, —C≡C—C3H7, —CH(CH3)—C≡CH, —CH2—CH(CH3)—C≡CH, —CH(CH3)—CH2—C≡CH, —CH(CH3)—C≡C—CH3, —C4H5—C≡CH, —C3H6—C≡C—CH3, —C2H4—C≡C—C2H5, —CH2—C≡C—C3H7, —C≡C—C4H9, —C2H4—CH(CH3)—C≡CH, —CH2—CH(CH3)—CH2—C≡CH, —CH(CH3)—C2H4—C≡CH, —CH2—CH(CH3)—C≡C—CH3, —CH(CH3)—CH2—C≡C—CH3, —CH(CH3)—C≡C—C2H5, —CH2—C≡C—CH(CH3)2, —C≡C—CH(CH3)—C2H5, —C≡C—CH2—CH(CH3)2, —C≡C—C(CH3)3, —CH(C2H5)—C≡C—CH3, —C(CH3)2—C≡C—CH3, —CH(C2H5)—CH2—C≡CH, —CH2—CH(C2H5)—C≡CH, —C(CH3)2—CH2—C≡CH, —CH2—C(CH3)2—C≡CH, —CH(CH3)—CH(CH3)—C≡CH, —CH(C3H7)—C≡CH, —C(CH3)(C2H5)—C≡CH, —C≡C—C≡CH, —CH2—C≡C—C≡CH, —C≡C—C≡C—CH3, —CH(C≡CH)2, —C2H4—C≡C—C≡CH, —CH2—C≡C—CH2—C≡CH, —C≡C—C2H4—C≡CH, —CH2—C≡C—C≡C—CH3, —C≡C—CH2—C≡C—CH3, —C≡C—C≡C—C2H5, —C≡C—CH(CH3)—C≡CH, —CH(CH3)—C≡C—C≡CH, —CH(C≡CH)—CH2—C≡CH, —C(C≡CH)2—CH3, —CH2—CH(C≡CH)2, —CH(C≡CH)—C≡C—CH3, —O—R89;
• R7, R8, R1° and R11, which may be the same or different, represent —H, —F, —Cl, —Br, —I, —CN, —NO2, —CH3, —C2H5, —C3H7, —CH(CH3)2, cyclo-C3H5, —CH2-cyclo-C3H5, —C4H9, —CH2—CH(CH3)2, —CH(CH3)—C2H5, —C(CH3)3, —CH(CH3)—C3H7, —CH2—CH(CH3)—C2H5, —CH(CH3)—CH(CH3)2, —C(CH3)2—C2H5, —CH2—C(CH3)3, —CH(C2H5)2, —C2H4—CH(CH3)2, —C6H13, —C3H6—CH(CH3)2, —C2H4—CH(CH3)—C2H5, —CH(CH3)—C4H9, —CH2—CH(CH3)—C3H7, —CH(CH3)—CH2—CH(CH3)2, —CH(CH3)—CH(CH3)—C2H5, —CH2—CH(CH3)—CH(CH3)2, —CH2—C(CH3)2—C2H5, —C(CH3)2—C3H7, —C(CH3)2—CH(CH3)2, —C2H4—C(CH3)3, —CH(CH3)—C(CH3)3, —CH═CH2, —CH2—CH═CH2, —C(CH3)═CH2, —CH═CH—CH3, —C2H4—CH═CH2, —CH2—CH═CH—CH3, —CH═CH—C2H5, —CH2—C(CH3)═CH2, —CH(CH3)—CH═CH, —CH═C(CH3)2, —C(CH3)═CH—CH3, —CH═CH—CH═CH2, —C3H6—CH═CH2, —C2H4—CH═CH—CH3, —CH2—CH═CH—C2H5, —CH═CH—C3H7, —CH2—CH═CH—CH═CH2, —CH═CH—CH═CH—CH3, —CH═CH—CH2—CH═CH2, —C(CH3)═CH—CH═CH2, —CH═C(CH3)—CH═CH2, —CH═CH—C(CH3)═CH2, —C2H4—C(CH3)═CH2, —CH2—CH(CH3)—CH═CH2, —CH(CH3)—CH2—CH═CH2, —CH2—CH═C(CH3)2, —CH2—C(CH3)═CH—CH3, —CH(CH3)—CH═CH—CH3, —CH═CH—CH(CH3)2, —CH═C(CH3)—C2H5, —C(CH3)═CH—C2H5, —C(CH3)═C(CH3)2, —C(CH3)2—CH═CH2, —CH(CH3)—C(CH3)═CH2, —C(CH3)═CH—CH═CH2, —CH═C(CH3)—CH═CH2, —CH═CH—C(CH3)═CH2, —C4H8—CH═CH2, —C3H6—CH═CH—CH3, —C2H4—CH═CH—C2H5, —CH2—CH═CH—C3H7, —CH═CH—C4H9, —C3H6—C(CH3)═CH2, —C2H4—CH(CH3)—CH═CH2, —CH2—CH(CH3)—CH2—CH═CH2, —CH(CH3)—C2H4—CH═CH2, —C2H4—CH═C(CH3)2, —C2H4—C(CH3)═CH—CH3, —CH2—CH(CH3)—CH═CH—CH3, —CH(CH3)—CH2—CH═CH—CH3, —CH2—CH═CH—CH(CH3)2, —CH2—CH═C(CH3)—C2H5, —CH2—C(CH3)═CH—C2H5, —CH(CH3)—CH═CH—C2H5, —CH═CH—CH2—CH(CH3)2, —CH═CH—CH(CH3)—C2H5, —CH═C(CH3)—C3H7, —C(CH3)═CH—C3H7, —CH2—CH(CH3)—C(CH3)═CH2, —CH(CH3)—CH2—C(CH3)═CH2, —CH(CH3)—CH(CH3)—CH═CH2, —CH2—C(CH3)2—CH═CH2, —C(CH3)2—CH2—CH═CH2, —CH2—C(CH3)═C(CH3)2, —CH(CH3)—CH═C(CH3)2, —C(CH3)2—CH═CH—CH3, —CH(CH3)—C(CH3)═CH—CH3, —CH═C(CH3)—CH(CH3)2, —C(CH3)═CH—CH(CH3)2, —C(CH3)═C(CH3)—C2H5, —CH═CH—C(CH3)3, —C(CH3)2—C(CH3)═CH2, —CH(C2H5)—C(CH3)═CH2, —C(CH3)(C2H5)—CH═CH2, —CH(CH3)—C(C2H5)═CH2, —CH2—C(C3H7)═CH2, —CH2—C(C2H5)═CH—CH3, —CH(C2H5)—CH═CH—CH3, —C(C4H9)═CH2, —C(C3H7)═CH—CH3, —C(C2H5)═CH—C2H5, —C(C2H5)═C(CH3)2, —C[C(CH3)3]═CH2, —C[CH(CH3)(C2H5)]═CH2, —C[CH2—CH(CH3)2]═CH2, —C2H4—CH═CH—CH═CH2, —CH2—CH═CH—CH2—CH═CH2, —CH═CH—C2H4—CH═CH2, —CH2—CH═CH—CH═CH—CH3, —CH═CH—CH2—CH═CH—CH3, —CH═CH—CH═CH—C2H5, —CH2—CH═CH—C(CH3)═CH2, —CH2—CH═C(CH3)—CH═CH2, —CH2—C(CH3)═CH—CH═CH2, —CH(CH3)—CH═CH—CH═CH2, —CH═CH—CH2—C(CH3)═CH2, —CH═CH—CH(CH3)—CH═CH2, —CH═C(CH3)—CH2—CH═CH2, —C(CH3)═CH—CH2—CH═CH2, —CH═CH—CH═C(CH3)2, —CH═CH—C(CH3)═CH—CH3, —CH═C(CH3)—CH═CH—CH3, —C(CH3)═CH—CH═CH—CH3, —CH═C(CH3)—C(CH3)═CH2, —C(CH3)═CH—C(CH3)═CH2, —C(CH3)═C(CH3)—CH═CH2, —CH═CH—CH═CH—CH═CH2, —C≡CH, —C≡C—CH3, —CH2—C≡CH, —C2H4—C≡CH, —CH2—C≡C—CH3, —C≡C—C2H5, —C3H6—C≡CH, —C2H4—C≡C—CH3, —CH2—C≡C—C2H5, —C≡C—C3H7, —CH(CH3)—C≡CH, —CH2—CH(CH3)—C≡CH, —CH(CH3)—CH2—C≡CH, —CH(CH3)—C≡C—CH3, —C4H8—C≡CH, —C3H6—C≡C—CH3, —C2H4—C≡C—C2H5, —CH2—C≡C—C3H7, —C≡C—C4H9, —C2H4—CH(CH3)—C≡CH, —CH2—CH(CH3)—CH2—C≡CH, —CH(CH3)—C2H4—C≡CH, —CH2—CH(CH3)—C≡C—CH3, —CH(CH3)—CH2—C≡C—CH3, —CH(CH3)—C≡C—C2H5, —CH2—C≡C—CH(CH3)2, —C≡C—CH(CH3)—C2H5, —C≡C—CH2—CH(CH3)2, —C≡C—C(CH3)3, —CH(C2H5)—C≡C—CH3, —C(CH3)2—C≡C—CH3, —CH(C2H5)—CH2—C≡CH, —CH2—CH(C2H5)—C≡CH, —C(CH3)2—CH2—C≡CH, —CH2—C(CH3)2—C≡CH, —CH(CH3)—CH(CH3)—C≡CH, —CH(C3H7)—C≡CH, —C(CH3)(C2H5)—C≡CH, —C≡C—C≡CH, —CH2—C≡C—C≡CH, —C≡C—C≡C—CH3, —CH(C≡CH)2, —C2H4—C≡C—C≡CH, —CH2—C≡C—CH2—C≡CH, —C≡C—C2H4—C≡CH, —CH2—C≡C—C≡C—CH3, —C≡C—CH2—C≡C—CH3, —C≡C—C≡C—C2H5, —C≡C—CH(CH3)—C≡CH, —CH(CH3)—C≡C—C≡CH, —CH(C≡CH)—CH2—C≡CH, —C(C≡CH)2—CH3, —CH2—CH(C≡CH)2, —CH(C≡CH)—C≡C—CH3, —O—R90, —O—R111, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl and C1-6alkoxy groups are optionally mono- or polysubstituted by —OH, —F, —Cl, —Br, —I;
• R9represents —H, —R91;
• R12 represent —R92, —CN, —R93, —R94, —OR94, phenyl, naphtalinyl, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl or C1-6alkoxy groups represented by R92 are optionally mono- or polysubstituted by —OH, —F, —Cl, —Br, —I, —O—R95, R96, —COOH, —COOCH3, —COOC2H5, —COOC3H7, —COOCH(CH3)2, —COOC(CH3)3, —(C═O)—NR16R17, —SO2—NR16R17, —SOm—R16R17, —CR16R17H, —NR16R17;
• and wherein the saturated or unsaturated three- to twelve-membered carbocyclic or heterocyclic ring systems represented by R137 are optionally mono- or polysubstituted by —OH, —F, —Cl, —Br, —I, —R96;
• R13 is selected from —H, —OH, —F, —Cl, —Br, —I, —NO2, —CH3, —C2H5, —C3H7, —CH(CH3)2, —C4H9, —CH2—CH(CH3)2, —CH(CH3)—C2H5, —C(CH3)3, —C5H11, —CH(CH3)—C3H7, —CH2—CH(CH3)—C2H5, —CH(CH3)—CH(CH3)2, —C(CH3)2—C2H5, —CH2—C(CH3)3, —CH(C2H5)2, —C2H4—CH(CH3)2, —C6H13, —C3H6—CH(CH3)2, —C2H4—CH(CH3)—C2H5, —CH(CH3)—C4H9, —CH2—CH(CH3)—C3H7, —CH(CH3)—CH2—CH(CH3)2, —CH(CH3)—CH(CH3)—C2H5, —CH2—CH(CH3)—CH(CH3)2, —CH2—C(CH3)2—C2H5, —C(CH3)2—C3H7, —C(CH3)2—CH(CH3)2, —C2H4—C(CH3)3, —CH(CH3)—C(CH3)3, —CH═CH2, —CH2—CH═CH2, —C(CH3)═CH2, —CH═CH—CH3, —C2H4—CH═CH2, —CH2—CH═CH—CH3, —CH═CH—C2H5, —CH2—C(CH3)═CH2, —CH(CH3)—CH═CH, —CH═C(CH3)2, —C(CH3)═CH—CH3, —CH═CH—CH═CH2, —C3H6—CH═CH2, —C2H4—CH═CH—CH3, —CH2—CH═CH—C2H5, —CH═CH—C3H7, —CH2—CH═CH—CH═CH2, —CH═CH—CH═CH—CH3, —CH═CH—CH2—CH═CH2, —C(CH3)═CH—CH═CH2, —CH═C(CH3)—CH═CH2, —CH═CH—C(CH3)═CH2, —C2H4—C(CH3)═CH2, —CH2—CH(CH3)—CH═CH2, —CH(CH3)—CH2—CH═CH2, —CH2—CH═C(CH3)2, —CH2—C(CH3)═CH—CH3, —CH(CH3)—CH═CH—CH3, —CH═CH—CH(CH3)2, —CH═C(CH3)—C2H5, —C(CH3)═CH—C2H5, —C(CH3)═C(CH3)2, —C(CH3)2—CH═CH2, —CH(CH3)—C(CH3)═CH2, —C(CH3)═CH—CH═CH2, —CH═C(CH3)—CH═CH2, —CH═CH—C(CH3)═CH2, —C4H8—CH═CH2, —C3H6—CH═CH—CH3, —C2H4—CH═CH—C2H5, —CH2—CH═CH—C3H7, —CH═CH—C4H9, —C3H6—C(CH3)═CH2, —C2H4—CH(CH3)—CH═CH2, —CH2—CH(CH3)—CH2—CH═CH2, —CH(CH3)—C2H4—CH═CH2, —C2H4—CH═C(CH3)2, —C2H4—C(CH3)═CH—CH3, —CH2—CH(CH3)—CH═CH—CH3, —CH(CH3)—CH2—CH═CH—CH3, —CH2—CH═CH—CH(CH3)2, —CH2—CH═C(CH3)—C2H5, —CH2—C(CH3)═CH—C2H5, —CH(CH3)—CH═CH—C2H5, —CH═CH—CH2—CH(CH3)2, —CH═CH—CH(CH3)—C2H5, —CH═C(CH3)—C3H7, —C(CH3)═CH—C3H7, —CH2—CH(CH3)—C(CH3)═CH2, —CH(CH3)—CH2—C(CH3)═CH2, —CH(CH3)—CH(CH3)—CH═CH2, —CH2—C(CH3)2—CH═CH2, —C(CH3)2—CH2—CH═CH2, —CH2—C(CH3)═C(CH3)2, —CH(CH3)—CH═C(CH3)2, —C(CH3)2—CH═CH—CH3, —CH(CH3)—C(CH3)═CH—CH3, —CH═C(CH3)—CH(CH3)2, —C(CH3)═CH—CH(CH3)2, —C(CH3)═C(CH3)—C2H5, —CH═CH—C(CH3)3, —C(CH3)2—C(CH3)═CH2, —CH(C2H5)—C(CH3)═CH2, —C(CH3)(C2H5)—CH═CH2, —CH(CH3)—C(C2H5)═CH2, —CH2—C(C3H7)═CH2, —CH2—C(C2H5)═CH—CH3, —CH(C2H5)—CH═CH—CH3, —C(C4H9)═CH2, —C(C3H7)═CH—CH3, —C(C2H5)═CH—C2H5, —C(C2H5)═C(CH3)2, —C[C(CH3)3]═CH2, —C[CH(CH3)(C2H5)]═CH2, —C[CH2—CH(CH3)2]═CH27—C2H4—CH═CH—CH═CH2, —CH2—CH═CH—CH2—CH═CH2, —CH═CH—C2H4—CH—CH2, CH2—CH—CH═CH—CH═CH3, CH—CH═CH2—CH—CH═CH3, —CH═CH—CH═CH—C2H5, —CH2—CH═CH—C(CH3)═CH2, —CH2—CH═C(CH3)—CH═CH2, —CH2—C(CH3)═CH—CH═CH2, —CH(CH3)—CH═CH—CH═CH2, —CH═CH—CH2—C(CH3)═CH2, —CH═CH—CH(CH3)—CH═CH2, —CH═C(CH3)—CH2—CH═CH2, —C(CH3)═CH—CH2—CH═CH2, —CH═CH—CH═C(CH3)2, —CH═CH—C(CH3)═CH—CH3, —CH═C(CH3)—CH═CH—CH3, —C(CH3)═CH—CH═CH—CH3, —CH═C(CH3)—C(CH3)═CH2, —C(CH3)═CH—C(CH3)═CH2, —C(CH3)═C(CH3)—CH═CH2, —CH═CH—CH═CH—CH═CH2, —C≡CH, —C≡C—CH3, —CH2—C≡CH, —C2H4—C≡CH, —CH2—C≡C—CH3, —C≡C—C2H5, —C3H6—C≡CH, —C2H4—C≡C—CH3, —CH2—C≡C—C2H5, —C≡C—C3H7, —CH(CH3)—C≡CH, —CH2—CH(CH3)—C≡CH, —CH(CH3)—CH2—C≡CH, —CH(CH3)—C≡C—CH3, —C4H8—C≡CH, —C3H6—C≡C—CH3, —C2H4—C≡C—C2H5, —CH2—C≡C—C3H7, —C≡C—C4H9, —C2H4—CH(CH3)—C≡CH, —CH2—CH(CH3)—CH2—C≡CH, —CH(CH3)—C2H4—C≡CH, —CH2—CH(CH3)—C≡C—CH3, —CH(CH3)—CH2—C≡C—CH3, —CH(CH3)—C≡C—C2H5, —CH2—C≡C—CH(CH3)2, —C≡C—CH(CH3)—C2H5, —C≡C—CH2—CH(CH3)2, —C≡C—C(CH3)3, —CH(C2H5)—C≡C—CH3, —C(CH3)2—C≡C—CH3, —CH(C2H5)—CH2—C≡CH, —CH2—CH(C2H5)—C≡CH, —C(CH3)2—CH2—C≡CH, —CH2—C(CH3)2—C≡CH, —CH(CH3)—CH(CH3)—C≡CH, —CH(C3H7)—C≡CH, —C(CH3)(C2H6)—C≡CH, —C≡C—C≡CH, —CH2—C≡C—C≡CH, —C≡C—C≡C—CH3, —CH(C≡CH)2, —C2H4—C≡C—C≡CH, —CH2—C≡C—CH2—C≡CH, —C≡C—C2H4—C≡CH, —CH2—C≡C—C≡C—CH3, —C≡C—CH2—C≡C—CH3, —C≡C—C≡C—C2H5, —C≡C—CH(CH3)—C≡CH, —CH(CH3)—C≡C—C≡CH, —CH(C≡CH)—CH2—C≡CH, —CH2—CH(C≡CH)2, —CH(C≡CH)—C≡C—CH3, cyclo-C3H5, —O—R97, —R98, —R99;
• when R12 and R13 represent alkenylene groups, R12 and R13 may combine to form a condensed aromatic ring together with the atoms of residue D to which R12 and R13 are attached in order to form a bicyclic group with residue D;
• R14 represents
• (i) —H, —OH, —F, —Cl, —Br, —I, —NO2, —CN, —NH2;
• (ii) —R100, —R101, —R102, —O—R102, —R103, —O—R103, —R136, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl and C1-6alkoxy groups represented by R100 and the ether groups represented by —R136 are optionally mono- or polysubstituted by —OH, —F, —Cl, —Br, —I, —O—R104, —R105, —COOH, —COOCH3, —COOC2H5, —COOC3H7, —COOCH(CH3)2, —COOC(CH3)3, —(C═O)—NR16R17, —SO2—NR16R17, —SOm—R16R17, —CR16R17H, —NR16R17;
• (iii) —R113, wherein the saturated or unsaturated three- to twelve-membered carbocyclic or heterocyclic ring system represented by —R113 is optionally mono- or polysubstituted by —F, —Cl, —Br, —I, —OH, —NO2, —NH2, —C2H4—N(CH3)2, —CN, —CF3, ═O, —R16, —R17, —R106, —O—R107, —R108, —R109, a saturated or unsaturated three- to eight-membered carbocyclic or heterocyclic group, wherein the C1-6alkyl groups represented by R106, the C1-6alkenyl groups represented by R108, the C2-6alkynyl groups represented by R109, the C1-6alkoxy groups represented by —O—R107 are optionally mono- or polysubstituted by —OH, —F, —Cl, —Br, —I, —O—R104, —R105, —COOH, —COOCH3, —COOC2H5, —COOC3H7, —COOCH(CH3)2, —COOC(CH3)3, —(C═O)—NR16R17, —SO2—NR16R17, —SOm—R16R17, —CR16R17H, —NR16R17;
• R16 and R17, which may be the same or different, represent —H, —R112, optionally substituted by —OH, —F, —Cl, —Br, —I, —NH2, —CN;
• or alternatively R16 and R17 may combine with the nitrogen atom attached thereto to form a saturated or unsaturated five to eight-membered heterocyclic group selected from —R114;
• which is optionally mono- or polysubstituted by —OH, ═O, —R116, —R117, —R118, —O—R119, —R120, or a saturated or unsaturated three- to twelve-membered carbocyclic or heterocyclic ring system selected from —R115;
• wherein the C1-6alkyl group represented by R116, Cmalkenyl group represented by R117, Cmalkynyl group represented by R118 are optionally substituted by —OH, —R122, or a saturated or unsaturated three- to twelve-membered carbocylic or heterocyclic ring system selected from —R121;
• amino group in which one or two hydrogen atoms on the amino group are optionally substituted by —R123, or a saturated or unsaturated three- to twelve-membered carbocyclic or heterocyclic ring system selected from —R124, and the C1-6alkyl group represented by R123 is optionally substituted by —OH, —R125, or a saturated or unsaturated three- to twelve-membered carbocylic or heterocyclic ring system selected from —R126;
• or a saturated or unsaturated three- to twelve-membered carbocyclic ring system selected from —R127;
• optionally substituted by —OH, ═O, —R128, —R129, —R130, —O—R131, —R132, or a saturated or unsaturated three- to twelve-membered carbocyclic or heterocyclic ring system selected from —R133, wherein the C1-6alkyl group represented by R128, C2-6alkenyl group represented by R129 and C2-6alkynyl group represented by R135 are optionally substituted by —OH, —R134, or a saturated or unsaturated three- to twelve-membered carbocyclic or heterocyclic ring system selected from —R135;
• when the carbocyclic or heterocyclic group is substituted by C1-6alkyl groups, two alkyl groups may combine together to form an alkylene chain;
• and the carbocyclic or heterocyclic group may be condensed with another saturated or unsaturated five to seven-membered carbocyclic or heterocyclic group to form a bicyclic group;
• R19, R20, R71, R85, R86, R89, R90, R91, R95, R97, R104, R106, R107, R110, R111, R112, R116, R119, R122, R123, R125, R128, R131 and R134 independently of each other represent —CH3, —H, —CF3, -Ph, —CH2-Ph, —C2H5, —C3H7, —CH(CH3)2, —C4H9, —CH2—CH(CH3)2, —CH(CH3)—C2H5, —C(CH3)3, —O5H11, —CH(CH3)—C3H7, —CH2—CH(CH3)—C2H5, —CH(CH3)—CH(CH3)2, —C(CH3)2—C2H5, —CH2—C(CH3)3, —CH(C2H5)2, —C2H4—C(CH3)2, —C6H13, —C3H6—CH(CH3)2, —C2H4—CH(CH3)—C2H5, —CH(CH3)—C4H9, —CH2—CH(CH3)—C3H7, —CH(CH3)—CH2—CH(CH3)2, —CH(CH3)—CH(CH3)—C2H5, —CH2—CH(CH3)—CH(CH3)2, —CH2—C(CH3)2—C2H5, —C(CH3)2—C3H7, —C(CH3)2—CH(CH3)2, —C2H4—C(CH3)3, —CH(CH3)—C(CH3)3;
• R21 and R98 represent independently of each other —CR22R23R24, —CR23R24—CR25R26R22—CR23R24—CR25R26—CR27R28R22, —CR23R24—CR25R26—CR27R28—CR29R30R22, —CR23R24—CR25R26—CR27R28—CR29R30—CR31R32R22, —CR23R24—CR25R26— CR27R28—CR29R30—CR31R32—CR33R34R22;
• R22-R34 independently of each other represent —H, —F, —Cl, —Br, —I, —CH3, —CF3, —OCH3, —OCF3, —C2H5, —C3H7;
• R35 and R99 represent independently of each other —O—CR22R23R24, —O—CR23R24—CR25R26R22, —O—CR23R24—CR25R26—CR27R28R22, O—CR23R24—CR25R26—CR27R28—CR29R30R22, —O—CR23R24—CR25R26—CR27R28—CR29R30—CR31R32R22, —O—CR23R24—CR25R26—CR27R28—CR29R30—CR31R32—CR33R34R22;
• R36, R72, R87, R96, R105, R120, R132 and R136 represent independently of each other —CR23R24—XH, —X—CR22R23R24, —X—CR23R24—CR25R26R22, —CR23R24—X—CR25R26R22, —CR23R24—CR25R26—XH, —X—CR23R24—CR25R26—CR27R28R22, —CR23R24—X—CR25R26—CR27R28R22, —CR23R24—CR25R26—X—CR27R28R22, —CR23R24—CR25R26—CR27R28—XH, —X—CR23R24—CR25R26—CR27R28—CR29R30R22, —CR23R24—X—CR28R28—CR27R28—CR29R30R22, —CR23R24—CR28R28—X—CR27R28—CR29R30R22, —CR23R24—CR25R26—CR27R28—X—CR29R30R22, —CR23R24—CR25R26—CR27R28—CR29R30—XH, —X—CR23R24—CR25R26—CR27R28—CR29R30—CR31R32R22, —CR23R24—X—CR25R26—CR27R28—CR29R30—CR31R32R22, —CR23R24—CR25R26—X—CR27R28—CR29R30—CR31R32R22—CR23R24—CR25R26—CR27R28—X—CR29R30—CR31R32R22, —CR23R24—CR25R26—CR27R28—CR29R30—X—CR31R32R22, —CR23R24—CR25R26—CR27R28—CR29R30—CR31R32—XH, —X—CR23R24—CR25R26—CR27R28—CR29R30—CR31R32—CR33R34R22, —CR23R24—X—CR25R26—CR27R28—CR29R30—CR31R32—CR33R34R22, —CR23R24—CR25R25—X—CR27R28—CR29R30—CR31R32—CR33R34R22, —CR23R24—CR25R26—CR27R28—X—CR29R30—CR31R32—CR33R34R22, —CR23R24—CR25R26—CR27R28—CR29R30—X—CR31R32—CR33R34R22, —CR23R24—CR25R26—CR27R28—CR29R30—CR31R32—X—CR33R34R22, —CR23R24—CR25R26—CR27R28—CR29R39—CR31R32—CR33R34—XH;
• X represents —O—, —CO—, —O—CO—
• R37, R38, R93 and R101 represent independently of each other —CR40R41—YH, —Y—CR39R40—R41, —Y—CR40—R41—CR42R43R39, —CR40R41—Y—CR42R43R39, —CR40R41—CR42R43—YH, —Y—CR40R41—CR42R43—CR44R45R39, —CR40R41—Y—CR42R43—CR44R45R39, —CR40R41—CR42R43—Y—CR44R45R39, —CR40R41—CR42R43—CR44R45—YH, —Y—CR40R41—CR42R43—CR44R45—CR46R47R39, —CR40R41—Y—CR42R43—CR44R45—CR46R47R39, —CR40R41—CR42R43—Y—CR44R45—CR46R47R39, —CR40R41—CR42R43—CR44R45—Y—CR46R46R39, —CR40R42—CR42R43—CR44R45—CR46R47—YH, —Y—CR40R41—CR42R43—CR44R45—CR46R47—CR48R49R39, —CR40R41—Y—CR42R43—CR44R45—CR46R47—CR48R49R39, —CR40R41—CR42R43—Y—CR44R45—CR46R47—CR48R49R39, —CR40R41—CR42R43—CR44R45—Y—CR46R47—CR48R49R39, —CR40R41—CR42R43—CR44R45—CR46R47—Y—CR48R49R39, —CR40R41—CR42R43—CR44R45—CR46R47—CR48R49—YH, —Y—CR40R41—CR42R43—CR44R45—CR46R47—CR46R49—CR50R51R39, —CR40R41—Y—CR42R43—CR44R45—CR46R47—CR48R49—CR50R51R39, —CR40R41—CR42R43—Y—CR44R45—CR46R47—CR48R49—CR50R51R39, CR40R41—CR42R43—CR44R45—Y—CR46R47—CR48R49—CR50R51R39, —CR40R41—CR42R43—CR44R45—CR46R47—Y—CR48R49—CR50R51R39, CR40R41—CR42R43—CR44R45—CR46R47—CR48R49—Y—CR50R51R39—CR4° R41—CR42R43—CR44R45—CR46R47—CR48R49—CR50R51—YH;
• R39-R53 represent independently of each other —H, —CH3, —C2H5, —C3H7;
• Y represents —NR52—CO—, —CO—NR53—;
• R54, R55 and R102 represent independently of each other
• R56, R57, R94 and R103 represent independently of each other —CR58R16R17, —CR69R60, —CR16R17CR61R62R58, —CR59R60—CR61R62R58, —R60R16R17R58, —CR16R17—CR61R62—CR63R64R58, —R59R60—CR61R62—CR63R64R58, —CR59R60—CR16R17—CR63R64R58, —CR59R60—CR61R62—CR16R17R58, R16R17—CR61R62—CR63R64—CR65R66R58, —CR59R60—CR61R62—CR63R64—CR65R66R58, —CR59R60—CR16R17—CR63R64—CR66R67R58, —CR59R60—CR61R62—CR16R17—CR65R66R58, —CR59R60—CR61R62—CR63R64—CR16R17R58, —R17—CR61R62—CR63R64—CR65R66—CR67R68R58, —CR69R60—CR61R62—CR63R64—CR65R66—CR67R68R58, —CR59R60—CR16R17—CR63R64—CR65R66—CR67R68R58, —CR59R60—CR61R62—CR16R17—CR65R66—CR67R68R69, —CR59R60—CR61R62—CR63R64—CR16R17—CR67R68R58, —CR59R60—CR61R62—CR63R64—CR65R66—CR16R17R58, —CR16R17—CR61R62—CR63R64—CR65R66—CR67R68—CR69R70R58, —CR59R60—CR16R17—CR63R64—CR65R66—CR67R68—CR69R76R58, —CR59R66—CR61R62—CR16R17—CR65R66—CR67R65—CR69R70R55, —CR59R60—CR61R62—CR63R64—CR16R17—CR67R68—CR69R70R55, —CR59R60—CR61R62—CR63R64—CR66R66—CR16R17—CR69R76R68, —CR59R66—CR61R62—CR63R64—CR65R66—CR67R68—CR16R17R58,
• R58-R70 represent independently of each other —H, —NH2, —OH, —F, —Cl, —Br, —I, —R71, —O—R71, —R72, —O—R95, —R96, —O—R104, —R105, —COOH, —COOCH3,
• —COOC2H5, —COOC3H7, —COOCH(CH3)2, —COOC(CH3)3, —(C═O)—NR16R17, —SO2—NR16R17, —SOm—R16R17, —CR16R17H, —NR16R17;
• R107, R117 and R129 represent independently of each other —CH═CH2, —CH2—CH═CH2, —H, —C(CH3)═CH2, —CH═CH—CH3, —C2H4—CH═CH2, —CH2—CH═CH—CH3, —CH═CH—C2H5, —CH2—C(CH3)═CH2, —CH(CH3)—CH═CH, —CH═C(CH3)2, —C(CH3)═CH—CH3, —CH═CH—CH═CH2, —C3H6—CH═CH2, —C2H4—CH═CH—CH3, —CH2—CH═CH—C2H5, —CH═CH—C3H7, —CH2—CH═CH—CH═CH2, —CH═CH—CH═CH—CH3, —CH═CH—CH2—CH═CH2, —C(CH3)═CH—CH═CH2, —CH═C(CH3)—CH═CH2, —CH═CH—C(CH3)═CH2, —C2H4—C(CH3)═CH2, —CH2—CH(CH3)—CH═CH2, —CH(CH3)—CH2—CH═CH2, —CH2—CH═C(CH3)2, —CH2—C(CH3)═CH—CH3, —CH(CH3)—CH═CH—CH3, —CH═CH—CH(CH3)2, —CH═C(CH3)—C2H5, —C(CH3)═CH—C2H5, —C(CH3)═C(CH3)2, —C(CH3)2—CH═CH2, —CH(CH3)—C(CH3)═CH2, —C(CH3)═CH—CH═CH2, —CH═C(CH3)—CH═CH2, —CH═CH—C(CH3)═CH2, —C4H8—CH═CH2, —C3H6—CH═CH—CH3, —C2H4—CH═CH—C2H5, —CH2—CH═CH—C3H7, —CH═CH—C4H9, —C3H6—C(CH3)═CH2, —C2H4—CH(CH3)—CH═CH2, —CH2—CH(CH3)—CH2—CH═CH2, —CH(CH3)—C2H4—CH═CH2, —C2H4—CH═C(CH3)2, —C2H4—C(CH3)═CH—CH3, —CH2—CH(CH3)—CH═CH—CH3, —CH(CH3)—CH2—CH═CH—CH3, —CH2—CH═CH—CH(CH3)2, —CH2—CH═C(CH3)—C2H5, —CH2—C(CH3)═CH—C2H5, —CH(CH3)—CH═CH—C2H5, —CH═CH—CH2—CH(CH3)2, —CH═CH—CH(CH3)—C2H5, —CH═C(CH3)—C3H7, —C(CH3)═CH—C3H7, —CH2—CH(CH3)—C(CH3)═CH2, —CH(CH3)—CH2—C(CH3)═CH2, —CH(CH3)—CH(CH3)—CH═CH2, —CH2—C(CH3)2—CH═CH2, —C(CH3)2—CH2—CH═CH2, —CH2—C(CH3)═C(CH3)2, —CH(CH3)—CH═C(CH3)2, —C(CH3)2—CH═CH—CH3, —CH(CH3)—C(CH3)═CH—CH3, —CH═C(CH3)—CH(CH3)2, —C(CH3)═CH—CH(CH3)2, —C(CH3)═C(CH3)—C2H5, —CH═CH—C(CH3)3, —C(CH3)2—C(CH3)═CH2, —CH(C2H5)—C(CH3)═CH2, —C(CH3)(C2H5)—CH═CH2, —CH(CH3)—C(C2H5)═CH2, —CH2—C(C3H7)═CH2, —CH2—C(C2H5)═CH—CH3, —CH(C2H5)—CH═CH—CH3, —C(C4H9)═CH2, —C(C3H7)═CH—CH3, —C(C2H5)═CH—C2H5, —C(C2H5)═C(CH3)2, —C[C(CH3)3]═CH2, —C[CH(CH3)(C2H5)]═CH2, —C[CH2—CH(CH3)2]═CH2, —C2H4—CH═CH—CH═CH2, —CH2—CH═CH—CH2—CH═CH2, —CH═CH—C2H4—CH═CH2, CH2—CH—CH═CH—CH═CH3, —CH═CH—CH2—CH═CH—CH3, —CH═CH—CH═CH—C2H5, —CH2—CH═CH—C(CH3)═CH2, —CH2—CH═C(CH3)—CH═CH2, —CH2—C(CH3)═CH—CH═CH2, —CH(CH3)—CH═CH—CH═CH2, —CH═CH—CH2—C(CH3)═CH2, —CH═CH—CH(CH3)—CH═CH2, —CH═C(CH3)—CH2—CH═CH2, —C(CH3)═CH—CH2—CH═CH2, —CH═CH—CH═C(CH3)2, —CH═CH—C(CH3)═CH—CH3, —CH═C(CH3)—CH═CH—CH3, —C(CH3)═CH—CH═CH—CH3, —CH═C(CH3)—C(CH3)═CH2, —C(CH3)═CH—C(CH3)═CH2, —C(CH3)═C(CH3)—CH═CH2, —CH═CH—CH═CH—CH═CH2;
• R109, R118 and R130 represent independently of each other —H, —C≡CH, —C≡C—CH3, —CH2—C≡CH, —C2H4—C≡CH, —CH2—C≡C—CH3, —C≡C—C2H5, —C3H6—C≡CH, —C2H4—C≡C—CH3, —CH2—C≡C—C2H5, —C≡C—C3H7, —CH(CH3)—C≡CH, —CH2—CH(CH3)—C≡CH, —CH(CH3)—CH2—C≡CH, —CH(CH3)—C≡C—CH3, —C4H8—C≡CH, —C3H6—C≡C—CH3, —C2H4—C≡C—CH5, —CH2—C≡C—C3H7, —C≡C—C4H9, —C2H4—CH(CH3)—C≡CH, —CH2—CH(CH3)—CH2—C≡CH, —CH(CH3)—C2H4—C≡CH, —CH2—CH(CH3)—C≡C—CH3, —CH(CH3)—CH2—C≡C—CH3, —CH(CH3)—C≡C—C2H5, —CH2—C≡C—CH(CH3)2, —C≡C—CH(CH3)—C2H5, —C≡C—CH2—CH(CH3)2, —C≡C—C(CH3)3, —CH(C2H5)—C≡C—CH3, —C(CH3)2—C≡C—CH3, —CH(C2H5)—CH2—C≡CH, —CH2—CH(C2H5)—C≡CH, —C(CH3)2—CH2—C≡CH, —CH2—C(CH3)2—C≡CH, —CH(CH3)—CH(CH3)—C≡CH, —CH(C3H7)—C≡CH, —C(CH3)(C2H5)—C≡CH, —C≡C—C≡CH, —CH2—C≡C—C≡CH, —C≡C—C≡C—CH3, —CH(C≡CH)2, —C2H4—C≡C—C≡CH, —CH2—C≡C—CH2—C≡CH, —C≡C—C2H4—C≡CH, —CH2—C≡C—C≡C—CH3, —C≡C—CH2—C≡C—CH3, —C≡C—C≡C—C2H5, —C≡C—CH(CH3)—C≡CH, —CH(CH3)—C≡C—C≡CH, —CH(C≡CH)—CH2—C≡CH, —C(C≡CH)2—CH3, —CH2—CH(C≡CH)2, —CH(C≡CH)—C≡C—CH3;
• R113, R115, R121, R124, R126, R127, R133, R135, R137 and R138 independently of each other represent
• R114 represents
• and enantiomers, stereoisomeric forms, mixtures of enantiomers, diastereomers, mixtures of diastereomers, prodrugs, hydrates, solvates, acid salt forms, tautomers, and racemates of the above mentioned compounds and pharmaceutically acceptable salts thereof.