Tetracyclic compounds

A compound of the Formula (E):

• wherein:
• R1 is H, hydroxyl, nitro, cyano, halo, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted C2-C8 alkenyl, substituted or unsubstituted C2-C8 alkynyl, perhaloalkyl, acyl, acyloxy, carbonylalkoxy, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkyl, C1-C8 perhaloalkoxy, alkoxy, aryloxy, carboxyl, thiol, thioalkyl, substituted or unsubstituted amino, acylamino, aminoacyl, aminocarbonylamino, aminocarbonyloxy, aminosulfonyl, sulfonylamino, sulfonyl or carbonylalkylenealkoxy;
• wherein acyl is selected from the group consisting of H—C(O)—, alkyl-C(O)—, substituted alkyl-C(O)—, alkenyl-C(O)—, substituted alkenyl-C(O)—, alkynyl-C(O)—, substituted alkynyl -C(O)—, aryl-C(O)—, substituted aryl-CO)—, heteroaryl-C(O)—, substituted heteroaryl-C(O)—, heterocyclic-C(O)—, and substituted heterocyclic-C(O)—;
• wherein sulfonylamino is selected from the group consisting of —SO2NH2, —SO2NR-alkyl, —SO2-substituted alkyl, —SO2NR-alkenyl, —SO2-substituted alkenyl, —SO2NR -alkynyl, —SO2-substituted alkynyl, —SO2NR-aryl, —SO2-substituted aryl, —SO2NR-heteroaryl, —SO2-substituted heteroaryl, —SO2NR-heterocyclic, and —SO2-substituted heterocyclic, where R is H or alkyl, or —SO2NR2, wherein the two R groups are taken together and with the nitrogen atom to which they are attached to form a heterocyclic or substituted heterocyclic ring;
• wherein sulfonyl is selected from the group consisting of —SO2-alkyl, —SO2-substituted alkyl, —SO2-alkenyl, —SO2-substituted alkenyl, —SO2-alkynyl, —SO2-substituted alkynyl, —SO2-aryl, —SO2-substituted aryl, —SO2-heteroaryl, —SO2-substituted heteroaryl, —SO2-heterocyclic, and —SO2-substituted heterocyclic;
• each R2a and R2b is independently H, substituted or unsubstituted C1-C8 alkyl, halo, hydroxyl, alkoxy, cyano, nitro or R2a and R2b are taken together to form a carbonyl moiety or R2a and R2b are taken together with the carbon to which they are attached to form a cycloalkyl moiety;
• each R3a and R3b is independently H, substituted or unsubstituted C1-C8 alkyl, halo, hydroxyl, alkoxy, cyano, nitro or R3a and R3b are taken together to form a carbonyl moiety or R3a and R3b are taken together with the carbon to which they are attached to form a cycloalkyl moiety;
• each X7, X8, X9 and X10 is independently CR4;
• m and q are independently 0 or 1;
• each R4 is independently H, hydroxyl, nitro, cyano, halo, C1-C8 perhaloalkyl, carboxy, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted C2-C8 alkenyl, substituted or unsubstituted C2-C8 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, C1-C8 perhaloalkoxy, C1-C8 alkoxy, aryloxy, carboxyl, carbonylalkoxy, thiol, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aralkyl, thioalkyl, substituted or unsubstituted amino, acylamino, aminoacyl, aminocarbonylamino, aminocarbonyloxy, aminosulfonyl, sulfonylamino, sulfonyl, carbonylalkylenealkoxy, alkylsulfonylamino or acyl;
• wherein acyl is selected from the group consisting of H—C(O)—, alkyl-C(O)—, substituted alkyl-C(O)—, alkenyl-C(O)—, substituted alkenyl-C(O)—, alkynyl-C(O)—, substituted alkynyl-C(O)—, aryl-C(O)—, substituted aryl-C(O)—, heteroaryl-C(O)—, substituted heteroaryl-C(O)—, heterocyclic-C(O)—, and substituted heterocyclic-C(O)—;
• wherein sulfonylamino is selected from the group consisting of —SO2NH2, —SO2NR-alkyl, —SO2-substituted alkyl, —SO2NR-alkenyl, —SO2-substituted alkenyl, —SO2NR-alkynyl, —SO2-substituted alkynyl, —SO2NR-aryl, —SO2-substituted aryl, —SO2NR-heteroaryl, —SO2-substituted heteroaryl, —SO2NR-heterocyclic, and —SO2-substituted heterocyclic, where R is H or alkyl, or —SO2NR2, wherein the two R groups are taken together and with the nitrogen atom to which they are attached to form a heterocyclic or substituted heterocyclic ring;
• wherein sulfonyl is selected from the group consisting of —SO2-alkyl, —SO2-substituted alkyl, —SO2-alkenyl, —SO2-substituted alkenyl, —SO2-alkynyl, —SO2-substituted alkynyl, —SO2-aryl, —SO2-substituted aryl, —SO2-heteroaryl, —SO2-substituted heteroaryl, —SO2-heterocyclic, and —SO2-substituted heterocyclic;
• each R8a, R8b, R8c, and R8d is independently H, hydroxyl, C1-C8 alkyl, C1-C8 perhaloalkyl, carboxy, carbonylalkoxy, or is taken together with the carbon to which it is attached and a geminal R8 to form a cycloalkyl moiety or a carbonyl moiety;
• R8e and R8f are taken together with the carbon to which they are attached to form a carbonyl moiety;
• each R10a and R10b is independently H, substituted or unsubstituted C1-C8 alkyl, halo, hydroxyl, alkoxy, cyano, nitro or R10a and R10b are taken together to form a carbonyl moiety or R10a and R10b are taken together with the carbon to which they are attached to form a cycloalkyl moiety;
• and
• Q is a substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl or substituted or a unsubstituted heterocyclyl;
• provided that at least one of (i)-(iii) applies:
• (i) Q is a substituted or unsubstituted piperidinyl, (ii) Q is an unsubstituted piperazinyl or a piperazinyl substituted with a branched alkyl group, and (iii) X9 is CR4 where R4 is halo, or a salt thereof.

A compound of the formula (B-1):

• wherein:
• R4 is halo or CH3;
• each X7, X8 and X10 is independently CR4A;
• each R4A is independently H, hydroxyl, nitro, cyano, halo, C1-C8 perhaloalkyl, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted C2-C8 alkenyl, substituted or unsubstituted C2-C8 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, C1-C8 perhaloalkoxy, C1-C8 alkoxy, aryloxy, carboxyl, carbonylalkoxy, thiol, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aralkyl, thioalkyl, substituted or unsubstituted amino, acylamino, aminoacyl, aminocarbonylamino, aminocarbonyloxy, aminosulfonyl, sulfonylamino, sulfonyl, carbonylalkylenealkoxy, alkylsulfonylamino or acyl;
• wherein acyl is selected from the group consisting of H—C(O)—, alkyl-C(O)—, substituted alkyl-C(O)—, alkenyl-C(O)—, substituted alkenyl-C(O)—, alkynyl-C(O)—, substituted alkynyl-C(O)—, aryl-C(O)—, substituted aryl-C(O)—, heteroaryl-C(O)—, substituted heteroaryl-C(O)—, heterocyclic-C(O)—, and substituted heterocyclic-C(O)—;
• wherein sulfonylamino is selected from the group consisting of —SO2NH2, —SO2NR-alkyl, —SO2-substituted alkyl, —SO2NR-alkenyl, —SO2-substituted alkenyl, —SO2NR-alkynyl, —SO2-substituted alkynyl, —SO2NR-aryl, —SO2-substituted aryl, —SO2NR-heteroaryl, —SO2-substituted heteroaryl, —SO2NR-heterocyclic, and —SO2-substituted heterocyclic, where R is H or alkyl, or —SO2NR2, wherein the two R groups are taken together and with the nitrogen atom to which they are attached to form a heterocyclic or substituted heterocyclic ring;
• wherein sulfonyl is selected from the group consisting of —SO2-alkyl, —SO2-substituted alkyl, —SO2-alkenyl, —SO2-substituted alkenyl, —SO2-alkynyl, —SO2-substituted alkynyl, —SO2-aryl, —SO2-substituted aryl, —SO2-heteroaryl, —SO2-substituted heteroaryl, —SO2-heterocyclic, and —SO2-substituted heterocyclic;
• each R8c and R8d is independently H, hydroxyl, C1-C8 alkyl, C1-C8 perhaloalkyl, carboxy, carbonylalkoxy, or are taken together with the carbon to which they are attached to form a cycloalkyl moiety or a carbonyl moiety;
• and
• Q is a substituted or unsubstituted heteroaryl or a substituted or unsubstituted heterocyclyl;
• or a salt thereof.