Substituted N- [1-cyano-2- (phenyl) ethyl] -2-azabicyclo [2.2.1] heptane-3-carboxamide inhibitors of cathepsin C

A compound of the formula I

• wherein
• n is 0 or 1;
• R1 is F—, HO—;
• R2 is selected from the group consisting of halogen, C1-6-alkyl-, C2-6-alkenyl-, C3-6-cycloalkyl-, C3-6-cycloalkenyl- or a ring system selected from the group consisting of
• a monocyclic C5-7-heterocyclyl-, wherein one or two carbon atoms are replaced by heteroatoms selected from —O— or —N— and the ring is fully or partially saturated, optionally substituted independently from each other with one or two R2.1;
• a bicyclic C8-10-heterocyclyl-, wherein one, two, three or four carbon atoms are replaced by heteroatoms selected from —S—, —O— or —N— and the ring is fully or partially saturated, optionally substituted independently from each other with one or two R2.1;
• aryl-, optionally substituted independently from each other with one or two R2.1;
• a C5-10-heteroaryl-, wherein one, two or three carbon atoms are replaced by heteroatoms selected from —O— or —N— and the ring is aromatic, optionally substituted independently from each other with one or two R2.1;
• R2.1 is Me-, F2HC—H2C—, O═, Me(O)C—, Et(O)C—, iPr(O)C—, nPr(O)C—, Me(O)2S—, Et(O)2S—, iPr(O)2S—, Me(O)2SO—, Me2N(O)C—, EtHN(O)C—, iPrHN(O)C—, cyclopropyl-(O)C—, phenyl-H2C—, MeO(CH2)3—, NC—, F—, Me2N(O)2S—, MeHN(O)2S—, MeOH2C—, Me2(HO)C—, cyclopropyl- or phenyl-, optionally substituted with MeO—;
• or a salt thereof.