Thieno[3,2-d]pyrimidine derivatives having inhibitory activity on protein kinases

A thieno[3,2-d]compound of formula (I), and a pharmaceutically acceptable salt thereof:

• wherein,
• Y is —CH═CR1—, —CC—, or —C(═O)NR1—;
• L is —C(═O)NR2—, —NR2C(═O)—, or —NR2C(═O)NR2—;
• R1 and R2 are each independently H, C1-6alkyl, or C3-8cycloalkyl;
• R is H, halogen, methyl, or methoxy;
• E is C3-14aryl or C2-13heteroaryl, which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of halogen, —NO2, —CN, —NH2, —OH, —CF3, C1-6alkyl, hydroxy-C1-6alkyl, C3-8cycloalkyl, —(CH2)n—C1-6alkylamino, —(CH2)n-diC1-6alkylamino, —(CH2)nC1-6alkoxy, —(CH2)n—OS(═O)2—C1-6alkyl, —(CH2)n—C3-14aryl, —(CH2)n—C2-13heteroaryl and —(CH2)n—C2-13heterocycloalkyl, wherein n is an integer number of 0 to 3, and the aryl, heteroaryl and heterocycloalkyl are each independently unsubstituted or substituted by a substituent selected from the group consisting of C1-6alkyl, hydroxy-C1-6alkyl, halogen, diC1-6alkylamino, and C1-6 alkoxy;
• and
• Z is H, —C(═O)R3, C1-6alkyl, hydroxyC1-6alkyl, C3-8cycloalkyl, C2-7heterocycloalkyl, C3-14aryl, or C2-13heteroaryl, wherein the aryl, heteroaryl, and heterocycloalkyl are each independently unsubstituted or substituted by C1-6alkyl, C1-6alkoxy, C3-8 cycloalkyl, R3—C2-7heterocycloalkyl or C2-7heterocycloalkyl, and R3 is C1-6alkyl, C3-6 cycloalkyl, or phenyl.