Administration of an anti-obesity compound to individuals with renal impairment

A method for weight management, for decreasing food intake, for inducing satiety, and/or for treating obesity in an individual in need thereof, comprising:

• administering a therapeutically effective amount of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine or a pharmaceutically acceptable salt, solvate or hydrate thereof to the individual,
• provided that the individual is selected from the group of individuals having no renal impairment, mild renal impairment, and moderate renal impairment.

A method for weight management, for decreasing food intake, for inducing satiety, and/or for treating obesity in an individual in need thereof, comprising:

• administering a therapeutically effective amount of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine or a pharmaceutically acceptable salt, solvate or hydrate thereof to the individual,
• provided that the individual has mild renal impairment or moderate renal impairment.

A method for weight management, for decreasing food intake, for inducing satiety, and/or for treating obesity in an individual in need thereof, comprising:

• determining the renal sufficiency level of the individual, and
• administering a therapeutically effective amount of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine or a pharmaceutically acceptable salt, solvate or hydrate thereof to the individual,
• provided that the individual does not have severe renal impairment or end stage renal disease.

A method for weight management, for decreasing food intake, for inducing satiety, and/or for treating obesity in an individual in need thereof, comprising:

• determining the renal sufficiency level of the individual, and
• administering a therapeutically effective amount of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine or a pharmaceutically acceptable salt, solvate or hydrate thereof to the individual,
• provided that the individual is selected from the group of individuals having no renal impairment, mild renal impairment, and moderate renal impairment.

A method for weight management, for decreasing food intake, for inducing satiety, and/or for treating obesity in an individual in need thereof, comprising:

• determining the renal sufficiency level of the individual, and
• administering a therapeutically effective amount of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine or a pharmaceutically acceptable salt, solvate or hydrate thereof to the individual,
• provided that the individual has mild renal impairment or moderate renal impairment.

A method for selecting an individual for treatment with (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine or a pharmaceutically acceptable salt, solvate or hydrate thereof, comprising

• determining the renal sufficiency level of the individual in need of treatment with (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine or a pharmaceutically acceptable salt, solvate or hydrate thereof,
• selecting an individual with a creatinine clearance rate of greater than about 30 mL/minute, and
• administering a therapeutically effective amount of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine or a pharmaceutically acceptable salt, solvate or hydrate thereof to the individual.