TGR5 modulators and methods of use thereof

A compound of formula A:

• or a salt, solvate, hydrate, or amino acid conjugate thereof, wherein:
• R1 is hydrogen, hydroxyl, substituted or unsubstituted alkyl, or halogen;
• R2 is hydrogen or hydroxyl;
• R4 is substituted or unsubstituted alkyl or halogen;
• R7 is hydrogen, substituted or unsubstituted alkyl, or hydroxyl;
• R11 is hydroxyl, OSO3H, OSO3−, OCOCH3, OPO3H, OPO32−, OC6H8O6−, or hydrogen;
• R12 is hydroxyl, OSO3H, OSO3−, OCOCH3, OPO3H, OPO32−, OC6H8O6−, or hydrogen, or taken together R11 and R12 form a carbonyl;
• and
• R16 is hydroxyl, alkoxy, or halogen.