Pharmaceutical formulation containing gelling agent
AssigneesPurdue Pharma L.P., The P.F. Laboratories, Inc., Purdue Pharmaceuticals L.P.
InventorsCurtis Wright, Benjamin Oshlack, Christopher Breder
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Abstract
Disclosed in certain embodiments is a controlled release oral dosage form comprising a therapeutically effective amount of a drug susceptible to abuse together with one or more pharmaceutically acceptable excipients; the dosage form further including a gelling agent in an effective amount to impart a viscosity unsuitable for administration selected from the group consisting of parenteral and nasal administration to a solubilized mixture formed when the dosage form is crushed and mixed with from about 0.5 to about 10 ml of an aqueous liquid; the dosage form providing a therapeutic effect for at least about 12 hours when orally administered to a human patient.
Claims8
An immediate release oral dosage form comprising:
- a mixture of (i) a therapeutically effective amount of oxycodone hydrochloride;
- (ii) a gelling agent comprising xanthan gum, the gelling agent in an effective amount to impart a viscosity of at least about 10 cP to a solubilized mixture formed when the dosage form is subject to tampering by dissolution in from about 0.5 to about 10 ml of an aqueous liquid;
- and (iii) an effective amount of an irritant to impart an irritating or burning sensation upon administration of a tampered dosage form;
- wherein the weight ratio of the xanthan gum to the oxycodone hydrochloride is from about 1:8 to about 8:1;
- and
- wherein the dosage form is in the form of a tablet and provides an immediate release of the oxycodone hydrochloride when the dosage form is orally administered to a human patient.
An immediate release oral dosage form comprising:
- a mixture of (i) a therapeutically effective amount of oxycodone hydrochloride;
- and (ii) a gelling agent comprising xanthan gum, the gelling agent in an effective amount to impart a viscosity of 120 cP or greater to a solubilized mixture formed when the dosage form is subject to tampering by dissolution in from about 0.5 to about 10 ml of an aqueous liquid;
- wherein the weight ratio of the xanthan gum to the oxycodone hydrochloride is from about 1:8 to about 8:1;
- and
- wherein the dosage form is in the form of a tablet and provides an immediate release of the oxycodone hydrochloride when the dosage form is orally administered to a human patient.
Dependencies are inferred from the claim text.