Drug for treating liver lesions caused by the action of chemical or biological agents
AssigneesViktor Veniaminovich TETS, Georgy Viktorovich TETS
InventorsViktor Veniaminovich TETS, Georgy Viktorovich TETS, Konstantin Andreevich Krasnov
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Abstract
The invention relates to medicine and can be used for treating liver lesions caused by chemical or biological agents. The drug for treating liver lesions caused by chemical or biological agents is embodied as 1-(4-bromophenyl)-6-hydroxy-5-nitroso-1,2,3,4-tetrahydropyrimidine-2.4-dione: (I), or salts thereof having the general formula: (II), where X is selected from Na+, K+, Li+, NH4+, NH2CONH3+ or another pharmacologically acceptable cation. The effectiveness of the preparation in treating liver diseases of different etiologies is increased.
Claims20
A solid reaction product comprising 1-(4-bromophenyl)-6-hydroxy-5-nitroso-1,2,3,4-tetrahydropyrimidine-2,4-dione:
- or a pharmacologically acceptable salt thereof,
- wherein said solid reaction product has a melting point of 220° C.
A method for synthesizing 1 (4 bromophenyl)-6-hydroxy-5-nitroso-1,2,3,4-tetrahydropyrimidine-2,4-dione:
- or a pharmacologically acceptable salt thereof, said method comprising the steps of:
- a. forming a solvated sodium metal by dissolving a sodium metal in anhydrous methanol;
- b. adding diethyl malonic ether to said solvated sodium metal;
- c. adding under heat and reflux N-(4-bromophenyl) urea to the diethyl malonic ether and solvated sodium metal mixture of step b;
- d. cooling the mixture of step c to 25° C. and diluting the mixture of step c with water;
- e. reacting the diluted mixture of step d with sodium nitrite to afford a clear solution;
- f. reacting the mixture of step e with acid to form a precipitate;
- g. filtering and washing said precipitate to afford (1-(4-bromophenyl)-6-hydroxy-5-nitroso-1,2,3,4-tetrahydropyrimidine-2,4-dione).
A solid reaction product comprising 1-(4-bromophenyl)-6-hydroxy-5-nitroso-1,2,3,4-tetrahydropyrimidine-2,4-dione:
- or a pharmacologically acceptable salt thereof, prepared by a process comprising the steps of:
- a. forming a solvated sodium metal by dissolving a sodium metal in anhydrous methanol;
- b. adding diethyl malonic ether to said solvated sodium metal;
- c. adding under heat and reflux N-(4-bromophenyl) urea to the diethyl malonic ether and solvated sodium metal mixture of step b;
- d. cooling the mixture of step c to 25° C. and diluting the mixture of step c with water;
- e. reacting the diluted mixture of step d with sodium nitrite to afford a clear solution;
- f. reacting the mixture of step e with acid to form a precipitate;
- g. filtering and washing said precipitate to afford said solid reaction product.
Dependencies are inferred from the claim text.