Compounds and methods for improving cellular uptake of oligomeric compounds
AssigneeIsis Pharmaceuticals, Inc.
InventorsErich Koller, C. Frank Bennett
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Abstract
The present invention provides method of optimizing the efficacy and potency of antisense drugs. In certain embodiments, the invention provides assays useful for determining favorable oligonucleotide characteristics and excipients for improved cellular uptake.
Claims19
A method of increasing the activity of first oligomeric compound in a cell, comprising contacting the cell with the first oligomeric compound in the presence of an excipient, wherein the excipient is a second oligomeric compound which is a non-sense oligomeric compound, wherein the first oligomeric compound is complementary to a target RNA in the cell, and wherein the second oligomeric compound is not complementary to any known sequence in the cell, wherein the first oligomeric compound and the second oligomeric compound each consists of 8 to 30 linked nucleosides, and wherein the first oligomeric compound and the second oligomeric compound each comprises at least one nucleotide with a 2′ modification.
Dependencies are inferred from the claim text.