Compositions and methods for silencing aldehyde dehydrogenase
AssigneeProtiva Biotherapeutics, Inc.
InventorsIan MacLachlan, Amy C. H. Lee
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Abstract
The present invention provides compositions comprising therapeutic nucleic acids such as interfering RNA (e.g., dsRNA such as siRNA) that target aldehyde dehydrogenase (ALDH) gene expression, lipid particles comprising one or more (e.g., a cocktail) of the therapeutic nucleic acids, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles (e.g., for treating alcoholism in humans).
Claims35
A composition comprising an interfering RNA that silences aldehyde dehydrogenase (ALDH) gene expression, wherein the interfering RNA comprises a sense strand and a complementary antisense strand, and wherein the interfering RNA comprises a double-stranded region of about 15 to about 60 nucleotides in length, wherein the interfering RNA is selected from the group consisting of siRNA Identifier 1 (SEQ ID NOs:11 & 12), siRNA Identifier 2 (SEQ ID NOs:13 & 12), siRNA Identifier 3 (SEQ ID NOs:14 & 15), siRNA Identifier 4 (SEQ ID NOs:16 & 15), siRNA Identifier 5 (SEQ ID NOs:17 & 18) and siRNA Identifier 6 (SEQ ID NOs:19 & 18).
Dependencies are inferred from the claim text.