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US 8,999,946 B2Granted
Chimeric adenoviral vectors
AssigneeVaxart, Inc.
InventorSean N. Tucker
Life of this patent
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Abstract
The present invention provides chimeric adenoviral vectors and methods for using the vectors to elicit an immune response to an antigen of interest.
Claims17
An immunogenic composition, said composition comprising:
- (a) a chimeric adenoviral expression vector comprising a promoter operably linked to a nucleic acid encoding a heterologous polypeptide, wherein the heterologous polypeptide is an human papilloma virus (HPV) polypeptide or herpes simplex virus (HSV) polypeptide;
- (b) a non-specific immune response enhancer selected from dsRNA and a dsRNA mimetic;
- and
- (c) a pharmaceutically acceptable carrier.
1 more element
A method for eliciting an immune response, the method comprising administering to a mammalian subject
- (a) a chimeric adenoviral expression vector comprising a promoter operably linked to a nucleic acid encoding a heterologous polypeptide, wherein the heterologous polypeptide is an human papilloma virus (HPV) polypeptide or herpes simplex virus (HSV) polypeptide;
- (b) a non-specific immune response enhancer selected from dsRNA and a dsRNA mimetic, wherein the immune response is directed against the heterologous polypeptide.
Dependencies are inferred from the claim text.