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US 8,999,945 B2Granted
Methods, compositions and systems for local delivery of drugs
AssigneeSilenseed Ltd.
InventorAmotz Shemi
Life of this patent
Estimating the term…
Abstract
Implantable medical device eluting drug locally and in a prolonged fashion are provided.
Claims14
A method of treating a solid tumor in a subject, the method comprising the step of implanting an implant within said solid tumor or into a tumor bed thereof, wherein said implant is a solid matrix that has a volume between 0.1-1000 mm3, and said solid matrix comprises:
- A. a biocompatible polymeric matrix, comprising a polymer selected from the group consisting of poly(glycolide-co-lactide) (PLGA), polylactic acid (PLA), polyglycolic acid (PGA), polyethylene glycol (PEG), and polycaprolactone (PCL);
- and
- B. an RNAi (RNA interference) agent that targets an oncogene or a tumor-promoting factor within said tumor, wherein said RNAi agent is incorporated within said biocompatible polymeric matrix and treats said tumor,
- wherein the amount of said RNAi agent is at least 1:20 weight/weight of the amount of said polymer in said biocompatible polymeric matrix.
1 more element
A method of treating a solid tumor in a subject, the method comprising the step of implanting an implant within said solid tumor or into a tumor bed thereof, wherein said implant is a solid matrix that has a volume between 0.1-1000 mm3, and said solid matrix comprises:
- A. a biocompatible polymeric matrix comprising poly(glycolide-co-lactide) (PLGA) and mannitol;
- and
- B. an RNAi (RNA interference) agent that targets an oncogene or a tumor-promoting factor within said tumor, wherein said RNAi agent is incorporated within said biocompatible polymeric matrix;
- wherein the amount of said RNAi agent is at least 1:20 weight/weight of the amount of said PLGA in said biocompatible polymeric matrix,
- and wherein said implant, when implanted into a subject's body tissue, treats said tumor and has an effective release period comprising 10 weeks.
2 more elements
Dependencies are inferred from the claim text.