Ophthalmic lipophilic drug delivery vehicle formulations

An ophthalmic drug delivery composition comprising:

• a. an ophthalmic drug;
• b. from 2% to 12% w/v of one or more nonionic surfactants selected from polysorbate 80, poloxamer 407, 2-hydroxypropyl cyclodextrin, polyoxyl 40 stearate, polyoxyl 40 dehydrogenated castor oil, or polyoxyl 35 castor oil;
• c. one or more non-Newtonian high blend viscosity enhancing, non-gelling agents selected from 0.5% to 0.8% w/v carboxymethyl cellulose (1%=2,500 cps at 27° C.), from 0.5% to 0.8% w/v hydroxypropyl methyl cellulose (2%=2,653-4,719 cps at 27° C. Dow Chemical Methocel F4M Premium), from 1.4% to 1.7% w/v hydroxypropyl cellulose (1%=2,900 cps) or a combination thereof;
• and
• d. from 0.10% to 0.90% w/v NaCl, such that:
• i. final composition viscosity at shear rates representative of a non-blinking eye is between 50 and 100 cps;
• ii. final composition viscosity at shear rates representative of a blinking eye of less than 30 cps but remaining above 5 cps, even after 30% dilution;
• and
• iii. a final composition ratio of i./ii. of 3:1 or greater,
• wherein w/v denotes weight by volume.