Soluble hydrophobic core carrier compositions for delivery of therapeutic agents, methods of making and using the same

A pharmaceutical composition, comprising:

• (i) a linear polymeric backbone;
• (ii) a plurality of hydrophilic polymeric protective side chains covalently linked and pendant to the linear polymeric backbone, wherein each hydrophilic polymeric protective side chain has a molecular weight between about 400 and about 20,000 Daltons;
• (iii) at least one hydrophobic moiety covalently linked and pendant to the linear polymeric backbone;
• and
• (iv) a load molecule dissociably linked to the at least one hydrophobic moiety covalently linked and pendant to the linear polymeric backbone,
• wherein the total weight ratio of the hydrophilic polymeric protective side chains and the hydrophobic moieties is in the range of 15:1 to 43:1 and wherein the composition is soluble in water and wherein the load molecule is a therapeutic agent.

A method of administering a therapeutic molecule to a subject comprising:

• administering to the subject a composition comprising:
• (i) a linear polymeric backbone;
• (ii) a plurality of hydrophilic polymeric protective side chains covalently linked and pendant to the linear polymeric backbone, wherein each hydrophilic polymeric protective side chain has a molecular weight between about 400 and about 20,000 Daltons;
• (iii) at least one hydrophobic moiety covalently linked and pendant to the linear polymeric backbone;
• (iv) a therapeutic molecule dissociably linked to the at least one hydrophobic moiety covalently linked and pendant to the linear polymeric backbone;
• wherein the total weight ratio of the hydrophilic polymeric protective side chains and the hydrophobic moieties is in the range of 15:1 to 43:1 and wherein the composition is soluble in water.

A composition comprising a hydrophobic-core carrier wherein the hydrophobic-core carrier consists essentially of:

• (i) a linear polymeric backbone;
• (ii) a plurality of hydrophilic polymeric protective side chains covalently linked and pendant to the linear polymeric backbone, wherein each hydrophilic polymeric protective side chain has a molecular weight between about 400 and about 20,000 Daltons;
• and
• (iii) at least one hydrophobic moiety covalently linked and pendant to the linear polymeric backbone;
• wherein the at least one hydrophobic moiety comprises an alkyl group of 6-36 carbons;
• wherein the total weight ratio of the hydrophilic polymeric protective side chains and the hydrophobic moieties is in the range of 15:1 to 43:1 and wherein the hydrophobic-core carrier is soluble in an aqueous solution essentially free of organic solvents.