Glial cell line-derived neurotrophic factor (GDNF) compositions and use thereof
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorQing-Rong Liu
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Abstract
Described herein is the identification of primate-specific glial cell line-derived neurotrophic factor opposite strand (GDNFOS) transcripts and encoded peptides. In particular embodiments, provided herein are three GDNFOS antisense transcripts, referred to as GDNFOS-1, GDNFOS-2 and GDNFOS-3. The GDNFOS-3 transcript encodes an ORF of 105 amino acids. Compositions comprising the GDNFOS transcripts and peptides are also provided by the present disclosure. Further provided are methods of treating a neurodegenerative or peripheral organ disease in a subject by administering a therapeutically effective amount of the disclosed GDNFOS nucleic acid molecules, peptides or compositions.
Claims21
A fusion protein comprising a glial cell line-derived neurotrophic factor opposite strand (GDNFOS) peptide and a heterologous protein, wherein the GDNFOS peptide comprises an amino acid sequence at least 90% identical to SEQ ID NO:
- 4 or at least 90% identical to residues 29-105 of SEQ ID NO:
- 4.
A composition comprising a glial cell line-derived neurotrophic factor opposite strand (GDNFOS) peptide encapsulated in a biodegradable microparticle or nanoparticle, wherein the GDNFOS peptide comprises an amino acid sequence at least 90% identical to SEQ ID NO:
- 4 or at least 90% identical to residues 29-105 of SEQ ID NO:
- 4.
Dependencies are inferred from the claim text.