Linear peptide antibiotics

A compound having the structure of Formula (I):

• wherein:
• R1 is selected from:
• R2, R4, R10, R11, R12, and R13 are each independently —H, —CH3, —CH(CH3)2, —C(CH3)3, —CH(CH3)(CH2CH3), —CH2CH(CH3)2, —CH2OH, —CH(OH)(CH3), —CH2CF3, —CH2C(O)OH, —CH2C(O)OR25, —CH2CH2C(O)OH, —CH2CH2C(O)OR25, —CH2C(O)NH2, —CH2CH2C(O)NH2, —CH2CH2C(O)N(H)C(H)(CH3)CO2H, —CH2CH2C(O)N(H)C(H)(CO2H)CH2CO2H, —CH2NR21R22, —(CH2)2NR21R22, —(CH2)3NR21R22, —(CH2)4NR21R22, —(CH2)4N(R25)3, —(CH2)4N(H)C(O)(2,3-dihydroxybenzene), optionally substituted C1-C8alkyl, optionally substituted C1-C8heteroalkyl, optionally substituted C3-C8cycloalkyl, optionally substituted —CH2—C3-C8cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl,
• R3 is methyl, ethyl, isopropyl, or cyclopropyl;
• R5 is H, methyl, ethyl, or —CH2OH;
• or R5 and R24 together with the boron atom form a 5- or 6-membered boron containing ring;
• R6 is —CH2C(═O)H, —B(OR23)(OR24), or
• or R5 and R6 together with the carbon atom form
• Rx is H, optionally substituted C1-C6alkyl, optionally substituted C1-C6heteroalkyl, or optionally substituted C3-C8cycloalkyl;
• or Rx and R2 together with the nitrogen atom form an optionally substituted nitrogen containing ring;
• Ry is H or methyl;
• or Ry and R5 together with the nitrogen atom form an optionally substituted nitrogen containing ring;
• Rz is —NR15R16, —CH2—NR15R16, or —(CH2)2—NR15R16;
• R7 is optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted alkenyl, or a linear or branched alkyl chain of about 1-22 carbon atoms, optionally comprising within the alkyl chain or at an alkyl chain terminus an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted heterocycloalkyl, or an optionally substituted
• wherein Z is a bond, O, S, NH, CH2, NHCH2, or C≡C;
• R8 is a bond, —O—, —N(R17)—, optionally substituted aryl, or optionally substituted heteroaryl;
• R9 is —CH2OH, —CH2CH(CH3)2,
• R15 and R16 are each independently H, or C1-C4alkyl;
• R17 is H, methyl, ethyl, isopropyl, or cyclopropyl;
• R18, R19, and R20 are each independently H, or methyl;
• each R21 is independently H, or C1-C4alkyl;
• each R22 is independently H, C1-C4alkyl, —C(═NH)(NH2), or —CH(═NH);
• R23 and R24 are each independently H, or C1-C4alkyl;
• or R23 and R24 together with the boron atom form an optionally substituted 5- or 6-membered boron containing ring;
• each R25 is independently C1-C6alkyl;
• R26 is H, C1-C4alkyl, C1-C4alkoxy, —CH2C(O)OR25, or —OCH2C(O)OR25;
• n is 0 or 1;
• p is 0 or 1;
• and
• q is 0 or 1;
• or a pharmaceutically acceptable salt, solvate, or prodrug thereof.