Methods for attenuating release of inflammatory mediators and peptides useful therein

A method of inhibiting the MARCKS-related release of at least one inflammatory mediator from a granule in at least one inflammatory cell in a tissue and/or fluid of a subject comprising:

• administration to said tissue and/or fluid a therapeutically effective amount of a pharmaceutical composition comprising a peptide having an amino acid sequence selected from the group consisting of:
• SEQ ID NOs:
• 106, 1, 11, 37, 45, 79, 91, 121, 143, 153, 219, 239, 248, 241, 251, 93, 108, 124, and 141, wherein
• the N-terminal amino acid of the peptide is chemically modified by acetylation;
• and
• wherein said peptide, optionally combined with a pharmaceutically acceptable carrier, and in a therapeutically effective inflammatory mediator release-reducing amount, reduces the amount of an inflammatory mediator released from at least one inflammatory cell as compared to release of said inflammatory mediator from at least one of the same type of inflammatory cell that would occur in the absence of said peptide.