Artificial mycolic acid membranes
AssigneeUniversity of Washington
InventorsJens Gundlach, Ian M. Derrington, Kyle W. Langford
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Abstract
Provided herein are artificial membranes of mycolic acids. The membranes may be unsupported or tethered. These membranes are long lived and highly resistant to electroporation, demonstrating their general strength. The mycolic acid membranes are suitable for controlled studies of the mycobacterial outer membrane and can be used in other experiments, such as nanopore analyte translocation experiments.
Claims19
An artificial bilayer membrane spanning the opening of an aperture, the membrane comprising a mycolic acid and having a rupture voltage greater than 0.5 V.
A system comprising an artificial bilayer membrane positioned between a first liquid conductive medium and a second liquid conductive medium, wherein the artificial membrane comprises a mycolic acid and has a rupture voltage greater than 0.5 V.
An artificial bilayer membrane spanning the opening of an aperture, wherein the membrane comprises a mycolic acid and can resist electroporation at an applied 200 mV for more than 24 hours.
Dependencies are inferred from the claim text.