Bifidobacterial gene sequences and their use
AssigneeThe Regents of the University of California
InventorsDavid A. Mills, Carlito B. Lebrilla, J. Bruce German, David Sela
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Abstract
This invention provides nucleic acids and proteins involved in oligosaccharide modification in the species Bifidobacteria. The invention provides methods for utilizing the proteins of the invention to generate human milk oligosaccharides or oligosaccharide mimics. The invention also provides compositions containing the human milk oligosaccharides or oligosaccharide mimics and methods for use.
Claims6
An isolated nucleic acid comprising a recombinant expression cassette comprising a promoter operably linked to a heterologous polynucleotide encoding a sialidase polypeptide comprising an amino acid sequence at least 90% identical to the amino acid sequence encoded by SEQ ID NO:1.
An expression vector comprising a promoter operably linked to a heterologous polynucleotide encoding a sialidase polypeptide comprising an amino acid sequence at least 90% identical to the amino acid sequence encoded by SEQ ID NO:1.
The expression vector wherein the polypeptide comprises the amino acid sequence encoded by SEQ ID NO:1.
Dependencies are inferred from the claim text.