Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms

A transformed cell having increased isoprenoid production as compared to a non-transformed cell, wherein said cell is produced by a method comprising:

• providing one or more isolated polynucleotides which together encode the enzymes of the complete mevalonate pathway;
• providing a plurality of target cells;
• introducing said isolated polynucleotide(s) into said target cells;
• selecting target cells which have been transformed with said polynucleotide(s);
• and
• growing said transformed cells under conditions whereby additional generations of descendant transformed cells are produced, said transformed cells exhibiting increased isoprenoid production as compared to non-transformed cells of the same type.

A method of increasing the production of isopentenyl pyrophosphate (IPP) via a mevalonate pathway in cells comprising:

• providing a plurality of target cells that do not naturally possess the mevalonate pathway;
• providing one or more isolated polynucleotides which together encode the enzymes of the complete mevalonate pathway;
• introducing said isolated polynucleotide(s) into said target cells;
• selecting target cells which have been transformed with said polynucleotide(s);
• and
• culturing the transformed cells under conditions whereby additional generations of descendant transformed cells are produced, said transformed cells exhibiting increased IPP production as compared to non-transformed cells of the same type.