Long-acting polypeptides and methods of producing same
AssigneeOPKO Biologics Ltd.
InventorsFuad Fares, Udi Eyal Fima
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Abstract
A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a carboxy terminus of a cytokine are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.
Claims4
A method of reducing a dosing frequency of a cytokine, comprising the step of attaching one chorionic gonadotrophin carboxy terminal peptide to the amino terminus of said cytokine and two chorionic gonadotrophin carboxy terminal peptides to the carboxy terminus of said cytokine, thereby reducing a dosing frequency of a cytokine.
Dependencies are inferred from the claim text.