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US 8,999,380 B2Granted
Modified polynucleotides for the production of biologics and proteins associated with human disease
AssigneeModerna Therapeutics, Inc.
InventorsStephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Sayda M. Elbashir, Matthias John, Atanu Roy, Susan Whoriskey, Kristy M. Wood, Paul Hatala, Jason P. Schrum, Kenechi Ejebe, Jeff Lynn Ellsworth, Justin Guild
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Abstract
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
Claims16
An isolated polynucleotide comprising;
- (a) a first region of linked nucleosides, said first region encoding a polypeptide of interest, said polypeptide of interest is SEQ ID NO:
- 1089;
- (b) a first flanking region located at the 5′ terminus of said first region comprising at least one 5′ terminal cap;
- (c) a second flanking region located at the 3′ terminus of said first region comprising a 3′ tailing sequence of linked nucleosides;
- and
- wherein at least one of said linked nucleosides of (a) comprises at least one modification as compared to the chemical structure of an A, G, U or C ribonucleoside.
3 more elements
Dependencies are inferred from the claim text.