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US 8,999,377 B2Granted
System for forming a biocompatible foam using polymerizable alpha(1-4)glucopyranose polymers and gas-producing component
AssigneeSurModics, Inc.
InventorsEmily R. Rolfes, Stephen J. Chudzik
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Abstract
Biocompatible foams having excellent physical and chemical properties are described. The biocompatible foams can be formed in situ or applied as a pre-formed foam for the treatment of tissue. The invention provides biocompatible degradable foams formed with a poly-α(1→4)glucopyranose macromer. The invention also provides biostable foams formed with a poly(alkylene oxide) macromer.
Claims23
A system for forming a biocompatible biodegradable foam comprising:
- a) a first covalently crosslinkable polymer comprising poly-α(1→4)glucopyranose and pendent free-radically polymerizable groups, wherein the poly-α(1→4)glucopyranose is maltodextrin;
- b) a second covalently crosslinkable polymer comprising an alkylene oxide polymer comprising pendent polymerizable groups;
- c) a polymerization initiator;
- and
- d) a gas-producing component comprising a bicarbonate salt and a biocompatible acid.
2 more elements
A system for forming a biocompatible biodegradable foam comprising:
- a) a first covalently crosslinkable polymer comprising a linear poly-α(1→4)glucopyranose having a molecular weight of 500,000 Da or less and comprising pendent free radically polymerizable groups;
- b) a second covalently crosslinkable polymer comprising an alkylene oxide polymer comprising pendent polymerizable groups;
- c) a Fe2+-based activator;
- d) a biocompatible acid;
- and
- e) a bicarbonate salt.
3 more elements
A system for forming a biocompatible biodegradable foam comprising:
- a) a first covalently crosslinkable polymer comprising poly-α(1→4)glucopyranose and pendent free-radically polymerizable groups;
- b) a second covalently crosslinkable polymer comprising an alkylene oxide polymer comprising pendent polymerizable groups;
- c) a polymerization initiator;
- and
- d) a water-soluble gas-producing component comprising a bicarbonate salt and a biocompatible acid;
- wherein the first and second covalently crosslinkable polymers, polymerization initiator, and gas-producing component are dissolvable in a physiologically compatible aqueous composition having a pH in the range of about 6.5 to about 7.5.
3 more elements
Dependencies are inferred from the claim text.