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US 8,999,376 B2Granted
Tissue patch
AssigneeXcede Technologies, Inc.
InventorDaniel Grant Ericson
Life of this patent
Estimating the term…
Abstract
Tissue patches and associated systems and methods are described. Certain embodiments are related to inventive systems and methods in which tissue patches can be made quickly and robustly without the use of complicated fabrication or sterilization equipment.
Claims41
A patch, comprising:
- a primer region comprising a water-activated polymeric adhesive;
- and
- an unsupported solid matrix comprising fibrin positioned over at least a portion of the primer region, wherein:
- the unsupported solid matrix has a Young's modulus of about 10 GPa or less after sterilization using gamma radiation at an intensity of 30 kGy, and
- the patch is configured for application to a tissue surface.
2 more elements
A patch, comprising:
- a primer region comprising a water-activated polymeric adhesive;
- and
- an unsupported solid matrix comprising fibrin positioned over at least a portion of the primer region, wherein:
- the fibrin within the unsupported solid matrix is cross-linked to a degree such that, after submerging the unsupported solid matrix in a 6M aqueous solution of urea at 25° C., the unsupported solid matrix retains its structural integrity over a period of at least about 2 hours, and
- the patch is configured for application to a tissue surface.
2 more elements
Dependencies are inferred from the claim text.