Prevention of bacterial contamination
AssigneeSinclair Pharmaceuticals Limited
InventorsJonathan Lane, Olof Torgny Sjodin
Life of this patent
Estimating the term…
Abstract
A compound of formula I: wherein R1 is a straight or branched alkyl group containing 8 to 16 carbon atoms at the 2- or 3-position of the morpholino ring, and R2 is a straight or branched alkyl group containing 2 to 10 carbon atoms, substituted with a hydroxy group except in the alpha-position, the sum of the carbon atoms in the groups R1 and R2 being at least 10 and preferably 10 to 20, is used to prevent biofilm formation on a surface. The compounds are particularly useful as coatings or treatments for medical devices, including stents, catheters and wire guides.
Claims24
A method for the inhibition of biofilm on a surface of a surgical implant, said method comprising coating or impregnating the surface of the implant prior to surgery with a material comprising a compound of formula (I) or a salt thereof:
- wherein R1 is a straight or branched alkyl group containing 8 to 16 carbon atoms at the 2- or 3-position of the morpholino ring, and R2 is a straight or branched alkyl group containing 2 to 10 carbon atoms, substituted with a hydroxy group except in the alpha-position, the sum of the carbon atoms in the groups R1 and R2 being at least 10 and preferably 10 to 20;
- wherein the implant is a transcutaneous device, catheter, stent, guide wire, or orthopedic prosthetic;
- and wherein the surface of the implant comprises metal.
A method for treating a biomedical device prior to use, comprising contacting the surface of the device with a compound of formula (I):
- wherein R1 is a straight or branched alkyl group containing 8 to 16 carbon atoms at the 2- or 3-position of the morpholino ring, and R2 is a straight or branched alkyl group containing 2 to 10 carbon atoms, substituted with a hydroxy group except in the alpha-position, the sum of the carbon atoms in the groups R1 and R2 being at least 10 and preferably 10 to 20;
- wherein the device is a transcutaneous device, catheter, stent, guide wire, or orthopedic prosthetic;
- and wherein the surface of the device comprises metal.
The method of 1, wherein the implant requires an incision to be made into the body to allow implantation of the implant.
Dependencies are inferred from the claim text.