HMGB1-derived peptides enhance immune response to antigens
AssigneeThe Regents of the University of California
InventorsDavorka Messmer, Rebecca Saenz
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Abstract
The invention provides an immunostimulatory peptide containing the amino acid sequence SAFFLFCSE and uses thereof. The invention also provides an immunostimulatory peptide containing the amino acid sequence DPNAPKRPPSAFFLX1X2X3X4 or derivatives thereof. In one embodiment, when X1 is alanine (A), glycine (G), or valine (V) then X2 is C, X3 is S and X4 is E; wherein when X2 is alanine (A), glycine (G), or valine (V) then X1 is F, X3 is S and X4 is E; wherein when X3 is alanine (A), glycine (G), or valine (V) then X1 is F, X2 is C and X4 is E; or wherein when X4 is alanine (A), glycine (G), or valine (V) then X1 is F, X2 is C and X3 is S.
Claims19
An isolated immunostimulatory peptide comprising the amino acid sequence DPNAPKRPPSAFFLX1X2X3X4 (SEQ ID NO:9),
- wherein the peptide comprises an alpha helix;
- and
- wherein X1 is alanine (A), glycine (G), or valine (V) and X2 is C, X3 is S and X4 is E;
- wherein X2 is alanine (A), glycine (G), or valine (V) and X1 is F, X3 is S and X4 is E;
- wherein X3 is alanine (A), glycine (G), or valine (V) and X1 is F, X2 is C and X4 is E;
- or
- wherein X4 is alanine (A), glycine (G), or valine (V) and X1 is F, X2 is C and X3 is S.
Dependencies are inferred from the claim text.