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US 8,999,348 B2Granted
Variants of group 6 allergens of the true grasses having reduced allergeneity due to mutagenesis of proline residues
AssigneeMerck Patent GmbH
InventorsMartin Wald, Andreas Nandy, Helmut Fiebig, Bernhard Weber, Helga Kahlert, Gerald Reese, Oliver Cromwell
Life of this patent
Estimating the term…
Abstract
The present invention relates to the preparation and use of recombinant variants of group 6 allergens of the Poaceae (true grasses), which are characterized by reduced IgE reactivity compared with known wild-type allergens and at the same time substantially retained reactivity with T-lymphocytes.
Claims10
A variant of a group 6 allergen of the true grass family (Poaceae) comprising a polypeptide sequence having at least 95% sequence identity to the wild-type Phl p 6 of SEQ ID NO:
- 2 and having a deletion or a substitution of at least one proline in position 29, 30, 57, or 79 in said SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.