Immunogenic control of tumours and tumour cells
AssigneesLife Sciences Research Partners VZW, Katholieke Universiteit Leuven
InventorJean-Marie Saint-Remy
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Abstract
The present invention relates to the use of immunogenic peptides comprising a T-cell epitope derived from a tumour-associated antigen and a redox motif such as C-(X)2-[CST] or [CST]-(X)2-C in the treatment of a tumour or in the treatment or prevention of a tumour relapse, and in the manufacture of medicaments therefore.
Claims9
A method of treating a tumor expressing a tumor associated antigen or of treating a relapse of a tumor expressing a tumor associated antigen comprising the step of administering, an immunogenic fusion peptide consisting of between 13 and 50 amino acids, comprising (i) an MHC Class II restricted T-cell epitope consisting of 8 or 9 amino acids of said tumor-associated antigen and (ii) a reducing C-(X)2-C motif, wherein X is not cysteine, which motif is separated from said T-cell epitope by a linker consisting of 1 or 2 amino acids.
Dependencies are inferred from the claim text.