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US 8,999,344 B2Granted
Immunoconjugates with an intracellularly-cleavable linkage
AssigneeImmunomedics, Inc.
InventorsSerengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg
Life of this patent
Estimating the term…
Abstract
The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
Claims18
A method for treating cancer comprising administering to a subject with cancer, wherein the cancer is a hematopoietic tumor, a sarcoma, a melanoma or a glial tumor, an immunoconjugate having a structural formula of MAb- CL2A-SN-38, with a structure represented by:
Dependencies are inferred from the claim text.