Antibodies that bind myostatin, compositions and methods
AssigneeAmgen Inc.
InventorsHuiquan Han, Taruna Arora, Qing Chen, Hsieng Sen Lu, Xiaolan Zhou
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Abstract
Myostatin antagonists, including myostatin binding antibodies, are disclosed. Also disclosed are nucleic acids encoding and cells including myostatin antagonists; methods of production; and methods of use.
Claims10
An isolated myostatin-specific antibody comprising at least one light chain and at least one heavy chain, wherein the light chain comprises a constant region and a variable region that comprises three complementarity determining regions (CDRs) and the heavy chain comprises a constant region and a variable region that comprises three CDRs, wherein the light chain CDRs are those disclosed in SEQ ID NO:39, SEQ ID NO:43, and SEQ ID NO:48, and the heavy chain CDRs are those disclosed in in SEQ ID NO:30, SEQ ID NO:33, and SEQ ID NO:36.
Dependencies are inferred from the claim text.