Methods for treating multiorgan, systemic degos' disease with a complement inhibitor
AssigneeAlexion Pharmaceuticals, Inc.
InventorCynthia Magro
Life of this patent
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Abstract
The present disclosure relates to, inter alia, compositions containing an inhibitor of human complement and/or an inhibitor of interferon alpha, and the use of the compositions in methods for treating or preventing Degos' disease in a subject. In some embodiments, the inhibitor is an antibody, or antigen-binding fragment thereof, that binds to a human complement component C5 protein or to a biologically-active fragment of C5 such as C5a or C5b. In some embodiments, the inhibitor is an antibody, or an antigen-binding fragment thereof, that binds to interferon alpha or to an interferon alpha receptor.
Claims18
A method for treating a patient afflicted with Degos' disease, the method comprising administering an antibody, or antigen-binding fragment thereof, that binds to a human complement component C5 protein, to a patient afflicted with Degos' disease, in an amount sufficient to treat the disease or lessen the severity of one or more symptoms of the disease, wherein the Degos' disease is multiorgan, systemic Degos' disease and wherein the one or more symptoms is selected from the group consisting of skin lesions, gastrointestinal bleeding, vomiting, enterocutaneous fistula, facial and acral paraesthesia, headaches, dizziness, aphagia, paraplegia, gaze palsy, epilepsy, memory loss, altered sensation, strokes, diplopia, ptosis, visual-field defects, weakness, shortness of breath, and chest pain.
A method for treating a patient afflicted with Degos' disease, the method comprising administering eculizumab to a patient afflicted with Degos' disease, in an amount sufficient to treat the disease or lessen the severity of one or more symptoms of the disease, wherein the Degos' disease is multiorgan, systemic Degos' disease and wherein the one or more symptoms is selected from the group consisting of skin lesions, gastrointestinal bleeding, vomiting, enterocutaneous fistula, facial and acral paraesthesia, headaches, dizziness, aphagia, paraplegia, gaze palsy, epilepsy, memory loss, altered sensation, strokes, diplopia, ptosis, visual-field defects, weakness, shortness of breath, and chest pain.
A method for treating a patient afflicted with Degos' disease, the method comprising administering pexelizumab to a patient afflicted with Degos' disease, in an amount sufficient to treat the disease or lessen the severity of one or more symptoms of the disease, wherein the Degos' disease is multiorgan, systemic Degos' disease and wherein the one or more symptoms is selected from the group consisting of skin lesions, gastrointestinal bleeding, vomiting, enterocutaneous fistula, facial and acral paraesthesia, headaches, dizziness, aphagia, paraplegia, gaze palsy, epilepsy, memory loss, altered sensation, strokes, diplopia, ptosis, visual-field defects, weakness, shortness of breath, and chest pain.
A method for treating a patient afflicted with Degos' disease, the method comprising administering a complement inhibitor to a patient afflicted with Degos' disease, in an amount sufficient to treat the disease or lessen the severity of one or more symptoms of the disease, wherein the Degos' disease is multiorgan, systemic Degos' disease, wherein the one or more symptoms is selected from the group consisting of skin lesions, gastrointestinal bleeding, vomiting, enterocutaneous fistula, facial and acral paraesthesia, headaches, dizziness, aphagia, paraplegia, gaze palsy, epilepsy, memory loss, altered sensation, strokes, diplopia, ptosis, visual-field defects, weakness, shortness of breath, and chest pain, and wherein the complement inhibitor is selected from the group consisting of soluble CR1, LEX-CR1, MCP, DAF, CD59, Factor H, cobra venom factor, FUT-175, complestatin, and K76 COOH.
Dependencies are inferred from the claim text.