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AssigneeJanssen Biotech, Inc.
InventorsJuan Carlos Almagro, Glenn Mark Anderson, Ellen Chi, Christian Martinez, Gopalan Raghunathan, Ronald Swanson, Alexey Teplyakov, Kam-Fai Tse, Sheng-Jiun Wu, Hong Mimi Zhou
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The invention relates to a humanized form of an antibody capable of preventing tissue factor (coagulation factor F3) signaling but which does not interfere with Factor VII binding or FX binding to tissue factor and does not prolong coagulation time. The antibody of the invention is useful in treating conditions, such as tumor progression, in which the associated cells express tissue factor and tissue factor signaling occurs.
An isolated anti-tissue factor antibody comprising:
An isolated anti-tissue factor antibody comprising an antibody heavy chain variable domain of SEQ ID NO:
Dependencies are inferred from the claim text.