Immunobinders directed against sclerostin

A binding protein comprising an antigen binding domain capable of binding human sclerostin, the antigen binding domain comprising three CDRs in a heavy chain and three CDRs in a light chain,

• wherein the heavy chain comprises a CDR-H1, a CDR-H2 and a CDR-H3;
• wherein the CDR-H1 comprises the amino acid sequence of X1-L-S-X2-H (residues 31-35 of SEQ ID NO:
• 1);
• wherein X1 is E or G;
• and
• wherein X2 is M, V or L;
• wherein the CDR-H2 comprises the amino acid sequence of G-X3-X4-P-E-X5-G-E-X6-I-Y-A-Q-K-F-Q-G (residues 50-66 of SEQ ID NO:
• 1);
• wherein X3 is F or S;
• wherein X4 is D or N;
• wherein X5 is D, E, V, Y, N, G, A, R, Q, H, F or I;
• and
• wherein X6 is T, I, L, M or N;
• and
• the CDR-H3 comprises the amino acid sequence of X7-X8-X9-X10-X11-W-X12-X13-X14-F-Q-H (residues 99-110 of SEQ ID NO:
• 1);
• wherein X7 is D or E;
• wherein X8 is S, T or A;
• wherein X9 is E, D, V, A, L, Y, W, Q, N, M, or G;
• wherein X10 is G or S;
• wherein X11 is Y, F, R, N, V, S, P or I;
• wherein X12 is E, Y, F or V;
• wherein X13 is K, Q or I;
• and
• wherein X14 is Y or F, and
• wherein the light chain comprises a CDR-L1, a CDR-L2 and a CDR-L3;
• wherein the CDR-L1 comprises an amino acid sequence of G-S-S-T-G-X15 V-T-X16-X17-H-Y-X18-Y (residues 23-36 of SEQ ID NO:
• 2),
• wherein X15 is A, D, P, G, S, N E, T or H;
• wherein X16 is S, I, V, T, G or M;
• wherein X17 is G, E, D, W, Y or N;
• and
• wherein X18 is P or T;
• wherein the CDR-L2 comprises the amino acid sequence of D-T-X19-X20-K-X21-S (residues 52-58 of SEQ ID NO:
• 2),
• wherein X19 is N, D, I, R, V, or T;
• wherein X20 is D or E;
• and
• wherein X21 is H, Q, N or D;
• and
• wherein the CDR-L3 comprises the amino acid sequence of L-L-X22-X23-X24X-25-X26-X27-V (residues 91-99 of SEQ ID NO:
• 2);
• wherein X22 is F or D;
• wherein X23 is Y, D, F, or N;
• wherein X24 is G or R;
• wherein X25 is G or S;
• wherein X26 is T, S, N or R;
• and
• wherein X27 is V, L, M or F.