Oncotherapeutic application of inhibitors of high-affinity glucose transporters
AssigneeUniversity of South Florida
InventorGeorge R. Simon
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Abstract
The subject invention concerns materials and methods for treating oncological disorders in a person or animal using any agent or compound that inhibits uptake of glucose into a cell. The subject invention also concerns methods for inducing apoptosis and inhibiting the proliferation or survival of a cell. In one embodiment, the methods comprise administering an effective amount of an agent or compound that inhibits the activity of one or more glucose transporter proteins, such as Glut-1. An antibody that binds to and inhibits a glucose transporter protein can be used in the present methods.
Claims26
A method for treating a person or animal, said method comprising administering an antibody, or antigen binding fragment thereof, that binds to glucose transporter-1 (Glut-1) protein, wherein the person or animal has breast or lung cancer.
A method for inhibiting the survival or proliferation of a breast cancer cell or lung cancer cell, said method comprising contacting said breast cancer cell or lung cancer cell with an effective amount of an antibody, or antigen binding fragment thereof, that binds to glucose transporter-1 (Glut-1) protein.
A method for treating breast cancer in a person or animal having the breast cancer, said method comprising parenterally administering a therapeutically effective amount of an antibody, or antigen binding fragment thereof, that binds to glucose transporter-1 (Glut-1) protein.
Dependencies are inferred from the claim text.