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US 8,999,322 B2Granted
Compositions and methods for modulating hemostasis
AssigneeThe United States of America National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS), NIH Division of Extramural Inventions and Technology Resources (DEITR)
InventorsSriram Krishnaswamy, Elsa P. Bianchini, Steven Orcutt
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Abstract
Novel thrombin/prothrombin protease/zymogen variants which have anticoagulation activity and methods of use thereof are disclosed.
Claims7
An isolated nucleic acid encoding a variant zymogen/protease which modulates hemostasis, said encoded variant having the sequence of SEQ ID NO:
- 1, wherein said encoded variant contains at least one modification in SEQ ID NO:
- 1 selected from the group consisting of:
- a) Ile at position 364 is replaced with Thr, or Val;
- b) Val at position 365 is replaced with Ala, or Ile, or Glu and c) Glu at position 366 is replaced with Thr, or Gly.
1 more element
Dependencies are inferred from the claim text.