Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases
AssigneesaTyr Pharma, Inc., Pangu BioPharma Limited
InventorsLeslie Ann Greene, Kyle P. Chiang, Fei Hong, Alain Philippe Vasserot, Jeffry D. Watkins, Cheryl L. Quinn, Wing-Sze Lo, John D. Mendlein
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Abstract
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Claims12
A therapeutic composition, comprising an isolated glycyl-tRNA synthetase (GlyRS) polypeptide that consists of SEQ ID NO:151 or differs from SEQ ID NO:151 by substitution, deletion, and/or addition of 1, 2, or 3 amino acids, wherein the polypeptide has an extracellular signaling activity and a solubility of at least about 5 mg/mL, and wherein the composition has a purity of at least about 95% on a protein basis and less than about 10 EU endotoxin/mg protein.
Dependencies are inferred from the claim text.