Methods and compositions related to the structure and function of APOBEC3G
AssigneeUniversity of Rochester
InventorsHarold C. Smith, Joseph E. Wedekind, Ryan Patrick Bennett
Life of this patent
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Abstract
Disclosed are methods and compositions related to the structure and function of APOBEC3G.
Claims6
A method of inhibiting viral infectivity in a cell comprising administering an inhibitor of the interaction between low molecular mass APOBEC3 G (LMM) dimers and high molecular mass APOBEC3G (HMM) conversion molecules to the cell, wherein the inhibitor stabilizes the LMM dimer, thereby inhibiting viral infectivity in the cell, wherein the inhibitor is selected from the group consisting of a small molecule, a peptide, a nucleic acid molecule, an antibody, and any combinations thereof, and wherein the inhibitor binds to at least one domain selected from the group consisting of the N-terminal pseudocatalytic domain and C-terminal pseudocatalytic domain of LMM.
A method of inhibiting viral infectivity in a cell comprising administering an inhibitor of the interaction between the N-terminal catalytic domain of low molecular mass APOBEC3G (LMM) and high molecular mass APOBEC3 G (HMM) conversion molecules to the cell, thereby inhibiting viral infectivity in the cell, wherein the inhibitor is selected from the group consisting of a small molecule, a peptide, a nucleic acid molecule, an antibody, and any Combinations thereof, and wherein the inhibitor binds to the N-terminal catalytic domain of LMM.
Dependencies are inferred from the claim text.